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Fig. 1 | Radiation Oncology

Fig. 1

From: Radiotherapy and the gut microbiome: facts and fiction

Fig. 1

The potential mechanisms of the gut microbiome regulating the response to radiotherapy. Notes: Radiotherapy may reshape tumor microenvironment by microbiome, which involve the unbalance of anti-inflammatory and pro-inflammatory cell and their corresponding cytokines. Oral probiotics, prebiotics, drug interventions and FMT may maintain balance in the gut microbiome and then reshape the tumor microenvironment. Other gut microbiome related mechanisms on regulating the response to radiotherapy include circadian rhythms, FIAF production, autophagy regulation, inflammation, production of SCFAs and butyrate and cancer-associated fibroblasts etc. RT radiotherapy, DC dendritic cells, IL interleukin, NK natural killer cells, TGF tumor growth factor, MDSC myeloid-derived suppressor cells, TNF tumor necrosis factor, IFN interferon, FMT fecal microbial transplant, FIAF fasting-induced adipose factor, SCFA short-chain fatty acids

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