Pattern of failure in prostate cancer previously treated with radical prostatectomy and post-operative radiotherapy: a secondary analysis of two prospective studies using novel molecular imaging techniques

Table 2 Clinical and treatment parameters for patients with isolated local recurrence

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7
Age at diagnosis (years)	56	57	54	53	55	55	62
NCCN risk group	High	Intermediate	High	Intermediate	Intermediate	Intermediate	Intermediate
Preoperative PSA (ng/ml)	4.5	4	4.9	5.7	4.20	10.00	6.80
Gleason score	7 (4 + 3)	7 (4 + 3)	8 (4 + 4)	7 (3 + 4)	6 (3 + 3)	6 (3 + 3)	7 (3 + 4)
Pathologic T-stage	T3b	T2c	T3a	T2	T2c	T2c	T2c
Pathologic N-stage	N0	N0	N0	N0	Nx	N0 (0/5)	N0 (0/8)
Extraprostatic extension	Present	None	Present	None	Negative	Negative	Negative
Seminal vesicle invasion	Present	None	None	None	Negative	Negative	Negative
Operative margins	Negative	Negative	Positive	Negative	Negative	Positive	Positive
Post-operative PSA	Undetectable	Undetectable	0.2	Undetectable	Detectable	0	2.23
Time to biochemical failure (months)	30.5	86.3	3.2	72.5	3.53	45.47	1.4
Adjuvant or Salvage Radiation	Adjuvant	Salvage	Salvage	Salvage	Salvage	Salvage	Salvage
Radiation field	Prostate fossa	Prostate fossa	Prostate fossa	Prostate fossa	Prostate Fossa	Prostate fossa	Prostate fossa + LN
Radiation dose prescription	7200 cGy	7020 cGy	6840 cGy	7200 cGy	7020 cGy	6660 cGy	6840 cGy
Recurrence within 100% isodose	Yes	Yes	Yes	No (outside of contour)	Yes	Yes	Yes
Dose to recurrence lesion	N/A	7020 cGy	6840 cGy	4900 cGy	7020 cGy	6660 cGy	N/A
PSA at ¹⁸F-PSMA PET/CT (ng/ml)	0.54	0.83	1.01	1.39	3.09	1.31	3.31

ISSN: 1748-717X