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Table 1 Patient characteristics for all patients, and subgroups of local, locoregional, and metastatic recurrence

From: Pattern of failure in prostate cancer previously treated with radical prostatectomy and post-operative radiotherapy: a secondary analysis of two prospective studies using novel molecular imaging techniques

  All patientsa Local recurrenceb Locoregional recurrencec Metastatic diseased
       Regional nodal and metastatic lesions Metastatic lesions alone
  n = 32 % n = 7 % n = 8 % n = 13 % n = 4 %
Median age at diagnosis 56.5 (range 52.5–73.7) 55.0 (range 53.0–61.5) 57.2 (range 53.1–69.4) 59.2 (range 53.0–73.7) 58.6 (range 52.5–66.8)
Tumor stage           
 T2 14 43.8% 5 62.5% 3 37.5% 3 23.1% 3 75.0%
 T3a 8 25.0% 1 12.5% 4 50.0% 3 23.1% 0 0%
 T3b 9 28.1% 1 12.5% 1 12.5% 6 46.2% 1 25.0%
 T4 1 3.1% 0 0.0% 0 0.0% 1 7.7% 0 0%
Nodal stage           
 N0 26 81.3% 6 75.0% 7 87.5% 10 76.9% 3 75.0%
 N1 1 3.1% 0 0.0% 0 0.0% 1 7.7% 0 0%
 Nx 5 15.6% 1 12.5% 1 12.5% 2 15.4% 1 25.0%
Gleason score           
 6 2 6.3% 2 25.0% 0 0.0% 0 0% 0 0%
 7 (3 + 4) 8 25.0% 2 25.0% 3 37.5% 1 7.7% 2 50.0%
 7 (4 + 3) 11 34.4% 2 25.0% 1 12.5% 8 61.5% 0 0%
 8 8 25.0% 1 12.5% 2 25.0% 4 30.8% 1 25.0%
 9 3 9.4% 0 0.0% 2 25.0% 0 0% 1 25.0%
Positive surgical margins 13 40.6% 3 37.5% 3 37.5% 7 53.8% 0 0%
 Median time to biochemical failure 30.1 mo (1.1–113.9) 30.5 mo (1.4–86.3) 27 mo (2.7–113.9) 15.8 mo (1.1–82.0) 49.9 mo (1.4–94.3)
 Median PSA at 18F-PSMA PET 2.4 ng/mL (0.38–22.37) 1.3 ng/ml (0.5–3.3) 1.6 ng/ml (0.4–8.9) 4.8 ng/ml (1.3–22.4) 5.4 ng/ml (2.0–7.9)
  1. aAll 32 patients included in the analysis of those who received PORT after prostatectomy prior to mpMRI and PSMA PET/CT imaging as per inclusion criteria
  2. bSubgroup of the 32 patients with local recurrence alone on mpMRI and PSMA PET/CT
  3. cSubgroup of the 32 patients who were found to have regional nodal recurrence (± local) on mpMRI and PSMA PET/CT
  4. dSubgroup of the 32 patients who were found to have metastatic (± local or regional nodal) disease on mpMRI and PSMA PET/CT