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Table 2 Logistic regression analyses of changes in MoCA score from baseline after WBRT

From: Patients with pretreatment leukoencephalopathy and older patients have more cognitive decline after whole brain radiotherapy

 

∆ MoCA score: baseline versus worst follow-up score

Odds ratio (95% CI) for MoCA score decline

p value

 

Median

Mean

Univariate analyses

  Agea

  

1.12 (1.04–1.21)

0.003

  WMH volumea

  

1.20 (1.06–1.52)

0.02

  Fazekas score (0–2); (Odds ratio: 0–2 versus 3–6)

0.0

− 1.7

6.4 (1.7–24.7)

0.007

  (3–6)

− 3.0

− 3.5

  

  Number of metastases (1–10)

  

1.0 (0.8–1.2)

1.0

  Volume of edema

  

1.005 (0.99–1.02)

0.4

Bivariate analyses

  Agea

  

1.08 (0.99–1.16)

0.05

  and  WMH volumea

  

1.14 (0.96–1.37)

0.14

  Agea

  

1.09 (1.01–1.18)

0.02

  and  Fazekas score (0–2 versus 3–6)

  

3.1 (0.7–14.1)

0.1

  1. MoCA Montreal Cognitive Assessment, WMH white matter hyperintensity
  2. aContinuous variables