Table 6 Summary of past CCRT studies for LAPC

Hammel et al. [2]

 Chemotherapy alone

III

63

–

–

–

16.5

8.4

46

N/A

44

N/A

 CRT

5

3D-CRT

54

Cap 800 mg/m²

15.2

9.9

32

60

Loehrer et al. [27]

 GEM alone

III

69

–

–

–

9.2

6.7

29.7

N/A

N/A

N/A

 CRT

66

3D-CRT

50.4

GEM 600 mg/m²

11.1

6

11.7

Chauffert et al. [29]

 GEM alone

III

62

–

–

–

13

N/A

N/A

N/A

N/A

N/A

 CRT

60

3D-CRT

60

5-FU/CDDP

8.6

Mukherjee et al. [28]

 GEM + RT

II

66

3D-CRT

50.4

GEM 300 mg/m²

13.4

10.4

55

N/A

68

N/A

 Cap + RT

63.1

Cap 830 mg/m²

15.2

12

47

47

Shibuya et al. [30]

II

65

3D-CRT

54

GEM 250 mg/m²

16.6

12

29

N/A

48

N/A

Miyamoto et al. [24]

Retro

78

3D-CRT (91.7%)

51.3 ± 2.0

5-FU (83.3%), 5-FU/GEM (12.5%)

8.6

N/A

20.8

N/A

66.7

N/A

Goto et al. [8]

 3D-CRT arm

Retro

65

3D-CRT

48.6–55.8

GEM 300 mg/m²

17.5

N/A

N/A

63.2

N/A

48.4

 IMRT arm

66

IMRT

39–51

GEM 1000 mg/m²

73.1

49.3

Krishnan et al. [31]

 BED > 70 Gy

Retro

64

IMRT (96%)

83.11 (BED)

Cap (79%), GEM (16%)

17.8

8.6

N/A

21

N/A

N/A

 BED ≤ 70 Gy

64

3D-CRT (91%)

59.47 (BED)

Cap (88%), GEM (11%)

15

5.3

9

Current study

Retro

78

IMRT

48

GEM 1000 mg/m²

20.4

13.5

26.7

73.3

53.3

66.7