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Table 3 Univariate analysis of risk factors for OS in the training cohort and validation cohort

From: Developing and validating an integrated gross tumor volume (GTV)-TNM stratification system for supplementing unresectable locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy

Factor

Training cohort

Validation cohort

3-year OS (%)

P value

3-year OS (%)

P value

Sex

 

0.100

 

0.268

 Male

57.9

 

50.1

 

 Female

69.6

 

65.1

 

Age (y)

 

0.088

 

0.072

 < 58

66.8

 

62.2

 

 ≥ 58

54.4

 

44.9

 

ECOG score

 

0.001

 

0.113

 0

68.2

 

76.0

 

 1

63.1

 

49.1

 

 2

33.1

 

53.3

 

Weight loss ≥ 5 kg

 

0.018

 

0.308

 Yes

38.7

 

33.3

 

 No

62.2

 

54.1

 

Smoke index ≥ 400

 

0.419

 

0.087

 Yes

56.8

 

44.5

 

 No

64.2

 

62.0

 

Pathological types

 

0.512

 

0.521

 Squamous cell carcinoma

56.2

 

60.1

 

 Non-squamous cell carcinoma

65.5

 

59.4

 

GTV risk group

 

 < 0.001

 

 < 0.001

 I

79.2

 

85.5

 

 II

56.8

 

46.4

 

 III

37.4

 

18.5

 

TNM stage

 

0.127

 

0.297

 IIIA

58.7

 

59.6

 

 IIIB

65.3

 

49.5

 

 IIIC

49.7

 

53.2

 

The integrated GTV-TNM stratification system

 

 < 0.001

 

 < 0.001

 Stratum A

78.4

 

82.4

 

 Stratum B

63.7

 

56.8

 

 Stratum C

38.1

 

24.7

 

Neoadjuvant chemotherapy

 

0.867

 

0.475

 Yes

59.6

 

56.1

 

 No

60.9

 

41.3

 

Adjuvant chemotherapy

 

0.382

 

0.713

 Yes

55.7

 

52.6

 

 No

61.2

 

52.9

 
  1. ECOG, Eastern Cooperative Oncology Group; GTV, gross tumor volume