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Table 5 Univariate analyses of clinical-pathological parameters for the prediction of cancer-specific survival, locoregional control and recurrence-free survival in patients treated with postoperative radio (chemo/immuno-) therapy

From: The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy

Patient characteristics

Cancer-specific survival

Locoregional control

Recurrence-free survival

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

Sex

 Male

1

 

1

 

1

 

 Female

1.49 (0.54–4.14)

0.445

1.50 (0.50–4.47)

0.471

1.15 (0.44–2.99)

0.778

Age at diagnosis

 < 60

1

 

1

 

1

 

 > 60

1.29 (0.45–3.68)

0.633

1.28 (0.44–3.70)

0.648

1.45 (0.59–3.51)

0.417

Smoking status

 Former or never

1

 

1

 

1

 

 Current

1.78 (0.56–5.64)

0.327

2.38 (0.66–8.68)

0.187

2.82 (0.94–8.50)

0.066

Alcohol consumption

 Former or never

1

 

1

 

1

 

 Current

0.77 (0.236–2.496)

0.661

1.52 (0.49–4.64)

0.468

1.76 (0.71–4.44)

0.220

Tumor grade

 G 1/2

1

 

1

 

1

 

 G 3/4

1.19 (0.383–3.723)

0.759

1.61 (0.45–5.79)

0.468

1.33 (0.48–3.67)

0.583

Tumor stage

 T 1/2

1

 

1

 

1

 

 T 3/4

2.48 (0.924–6.644)

0.071

3.20 (1.10–9.31)

0.033

2.85 (1.17–6.89)

0.021

Nodal involvement

 N0

1

 

1

 

1

 

 N+

2.67 (0.33–21.89)

0.359

1.29 (0.16–10.25)

0.808

1.96 (0.26–15.11)

0.517

Induction chemotherapy

 Yes

1

 

1

 

1

 

 No

0.10 (0.03–0.39)

0.001

9.19 (2.51–33.69)

0.001

5.90 (1.69–20.49)

0.005

Concomitant chemotherapy

 Yes

1

 

1

 

1

 

 No

0.36 (0.11–1.16)

0.086

0.24 (0.07–0.87)

0.030

0.29 (0.10–0.79)

0.016

Chemo-/Immunotherapy

 No

1

 

1

 

1

 

 Erbitux

n.a

0.984

n.a

0.983

n.a

0.98

 Cisplatin

0.37 (0.12–1.19)

0.095

0.25 (0.07–0.90)

0.035

0.29 (0.11–0.82

0.019

RTx technique

 3D conformal

1

 

1

 

1

 

 IMRT

1.34 (0.40–4.45)

0.634

0.70 (0.21–2.33)

0.562

0.76 (0.28–2.07)

0.595

RTx total dose

 ≤ 60

1

 

1

 

1

 

 > 60 to < 70

1.32 (0.40–4.34)

0.652

3.28 (0.72–14.98)

0.125

0.99 (0.38–2.56)

0.984

 ≥ 70

1.77 (0.39–8.09)

0.461

2.93 (0.41–20.79)

0.283

0.80 (0.17–3.87)

0.783

Platelet count (G/L)

 Median (mean ± SD)

1.002 (0.997–1.007)

0.404

1.002 (0.99–1.007)

0.535

1.002 (0.99–1.006)

0.516

MPV (fL)

 Median (mean ± SD)

0.87 (0.67–01.11)

0.257

0.83 (0.65–1.06)

0.128

0.87 (0.69–1.09)

0.239

  1. MPV, mean platelet volume; HR, hazard ratio; CI, confidence interval; SD, standard deviation; IMRT, intensity modulated radiation therapy