Patient characteristics | Cancer-specific survival | Locoregional control | Recurrence-free survival | |||
---|---|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
Sex | ||||||
Male | 1 | 1 | 1 | |||
Female | 1.49 (0.54–4.14) | 0.445 | 1.50 (0.50–4.47) | 0.471 | 1.15 (0.44–2.99) | 0.778 |
Age at diagnosis | ||||||
< 60 | 1 | 1 | 1 | |||
> 60 | 1.29 (0.45–3.68) | 0.633 | 1.28 (0.44–3.70) | 0.648 | 1.45 (0.59–3.51) | 0.417 |
Smoking status | ||||||
Former or never | 1 | 1 | 1 | |||
Current | 1.78 (0.56–5.64) | 0.327 | 2.38 (0.66–8.68) | 0.187 | 2.82 (0.94–8.50) | 0.066 |
Alcohol consumption | ||||||
Former or never | 1 | 1 | 1 | |||
Current | 0.77 (0.236–2.496) | 0.661 | 1.52 (0.49–4.64) | 0.468 | 1.76 (0.71–4.44) | 0.220 |
Tumor grade | ||||||
G 1/2 | 1 | 1 | 1 | |||
G 3/4 | 1.19 (0.383–3.723) | 0.759 | 1.61 (0.45–5.79) | 0.468 | 1.33 (0.48–3.67) | 0.583 |
Tumor stage | ||||||
T 1/2 | 1 | 1 | 1 | |||
T 3/4 | 2.48 (0.924–6.644) | 0.071 | 3.20 (1.10–9.31) | 0.033 | 2.85 (1.17–6.89) | 0.021 |
Nodal involvement | ||||||
N0 | 1 | 1 | 1 | |||
N+ | 2.67 (0.33–21.89) | 0.359 | 1.29 (0.16–10.25) | 0.808 | 1.96 (0.26–15.11) | 0.517 |
Induction chemotherapy | ||||||
Yes | 1 | 1 | 1 | |||
No | 0.10 (0.03–0.39) | 0.001 | 9.19 (2.51–33.69) | 0.001 | 5.90 (1.69–20.49) | 0.005 |
Concomitant chemotherapy | ||||||
Yes | 1 | 1 | 1 | |||
No | 0.36 (0.11–1.16) | 0.086 | 0.24 (0.07–0.87) | 0.030 | 0.29 (0.10–0.79) | 0.016 |
Chemo-/Immunotherapy | ||||||
No | 1 | 1 | 1 | |||
Erbitux | n.a | 0.984 | n.a | 0.983 | n.a | 0.98 |
Cisplatin | 0.37 (0.12–1.19) | 0.095 | 0.25 (0.07–0.90) | 0.035 | 0.29 (0.11–0.82 | 0.019 |
RTx technique | ||||||
3D conformal | 1 | 1 | 1 | |||
IMRT | 1.34 (0.40–4.45) | 0.634 | 0.70 (0.21–2.33) | 0.562 | 0.76 (0.28–2.07) | 0.595 |
RTx total dose | ||||||
≤ 60 | 1 | 1 | 1 | |||
> 60 to < 70 | 1.32 (0.40–4.34) | 0.652 | 3.28 (0.72–14.98) | 0.125 | 0.99 (0.38–2.56) | 0.984 |
≥ 70 | 1.77 (0.39–8.09) | 0.461 | 2.93 (0.41–20.79) | 0.283 | 0.80 (0.17–3.87) | 0.783 |
Platelet count (G/L) | ||||||
Median (mean ± SD) | 1.002 (0.997–1.007) | 0.404 | 1.002 (0.99–1.007) | 0.535 | 1.002 (0.99–1.006) | 0.516 |
MPV (fL) | ||||||
Median (mean ± SD) | 0.87 (0.67–01.11) | 0.257 | 0.83 (0.65–1.06) | 0.128 | 0.87 (0.69–1.09) | 0.239 |