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Table 3 Multivariate analyses of clinical-pathological parameters for the prediction of cancer-specific survival, locoregional control and recurrence-free survival

From: The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy

 

Cancer-specific survival*

Locoregional control*

Recurrence-free survival*

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

Smoking status

 Former/never

1

 

1

 

1

 

 Current

2.38 (1.25–4.53)

0.008

1.96 (1.09–3.50)

0.023

2.08 (1.21–3.60)

0.008

Alcohol consumption

 Former or never

1

 

1

 

1

 

 Current

0.99 (0.57–1.72)

0.973

1.06 (0.63–1.78)

0.818

1.12 (0.69–1.80)

0.65

Tumor stage

 T 1/2

1

 

1

 

1

 

 T 3/4

1.76 (0.79–3.92)

0.165

2.67 (1.13–6.28)

0.024

1.91 (0.93–3.89)

0.076

Surgery

 No

1

 

1

 

1

 

 Yes

0.25 (0.12–0.54)

< 0.001

0.26 (0.13–0.53)

< 0.001

0.33 (0.17–0.62)

0.001

Induction chemotherapy

 No

1

 

1

 

1

 

 Yes

0.79 (0.43–1.43)

0.429

0.80 (0.47–1.37)

0.428

0.92 (0.56–1.52)

0.753

Platelet count (continuous)

1.001 (0.999–1.004)

0.304

1.002 (1.000–1.004)

0.121

1.002 (0.999–1.004)

0.174

MPV (continuous)

0.77 (0.63–0.93)

0.008

0.80 (0.65–0.98)

0.030

0.83 (0.685–0.999)

0.049

  1. MPV, mean platelet volume; HR, hazard ratio; CI, confidence interval
  2. *Adjustment for all factors significantly associated in univariate analysis