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Table 3 Univariate analysis of the development of osteoradionecrosis of the jaw

From: Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma

Variable

HR

95% CI

P value

Age

0.999

0.972–1.026

0.9433

Sex

1.347

0.570–3.180

0.4972

History of smoking

1.489

0.664–3.338

0.3336

History of alcohol use

1.037

0.524–2.052

0.9178

Diabetes mellitus

1.247

0.579–2.682

0.5728

Performance status (0–1 vs. 2–4)

1.608

0.707–3.655

0.2573

Pre-RT dental evaluation

1.280

0.623–2.673

0.5017

Pre-RT tooth extraction

1.469

0.819–2.636

0.1971

Post-RT tooth extraction

2.630

1.350–5.125

0.0045

Tumor site (OPC/OC vs. others)

6.667

2.824–15.74

 < 0.0001

T-stage (x, 0–2 vs. 3–4)

0.937

0.497–1.768

0.8410

Lymph node positive

1.408

0.657–3.020

0.3794

Pre-RT surgery

1.713

0.960–3.056

0.0687

Pre-RT mandible surgery

3.053

1.356–6.875

0.0070

Induction chemotherapy

0.748

0.232–2.411

0.6267

Concurrent chemotherapy

2.528

0.997–6.411

0.0507

RT technique (3D-CRT vs. IMRT)

0.886

0.380–2.063

0.7789

Total radiation dose

0.976

0.915–1.041

0.4587

V60 (≤ 14% vs. > 14%)

6.969

2.745–17.700

 < 0.0001

  1. HR, hazard ratio; CI, confidence interval; RT, radiation therapy; OPC, oropharyngeal cancer; OC, oral cancer; 3D-CRT, 3-dimensional conformal radiation therapy; IMRT, intensity-modulated radiation therapy; V60, relative volumes of the jaw exposed to 60 Gy
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Radiation Oncology

ISSN: 1748-717X

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