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Table 3 Univariate analysis of the development of osteoradionecrosis of the jaw

From: Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma

Variable HR 95% CI P value
Age 0.999 0.972–1.026 0.9433
Sex 1.347 0.570–3.180 0.4972
History of smoking 1.489 0.664–3.338 0.3336
History of alcohol use 1.037 0.524–2.052 0.9178
Diabetes mellitus 1.247 0.579–2.682 0.5728
Performance status (0–1 vs. 2–4) 1.608 0.707–3.655 0.2573
Pre-RT dental evaluation 1.280 0.623–2.673 0.5017
Pre-RT tooth extraction 1.469 0.819–2.636 0.1971
Post-RT tooth extraction 2.630 1.350–5.125 0.0045
Tumor site (OPC/OC vs. others) 6.667 2.824–15.74  < 0.0001
T-stage (x, 0–2 vs. 3–4) 0.937 0.497–1.768 0.8410
Lymph node positive 1.408 0.657–3.020 0.3794
Pre-RT surgery 1.713 0.960–3.056 0.0687
Pre-RT mandible surgery 3.053 1.356–6.875 0.0070
Induction chemotherapy 0.748 0.232–2.411 0.6267
Concurrent chemotherapy 2.528 0.997–6.411 0.0507
RT technique (3D-CRT vs. IMRT) 0.886 0.380–2.063 0.7789
Total radiation dose 0.976 0.915–1.041 0.4587
V60 (≤ 14% vs. > 14%) 6.969 2.745–17.700  < 0.0001
  1. HR, hazard ratio; CI, confidence interval; RT, radiation therapy; OPC, oropharyngeal cancer; OC, oral cancer; 3D-CRT, 3-dimensional conformal radiation therapy; IMRT, intensity-modulated radiation therapy; V60, relative volumes of the jaw exposed to 60 Gy