Report on planning comparison of VMAT, IMRT and helical tomotherapy for the ESCALOX-trial pre-study

Pigorsch, Steffi U.; Kampfer, Severin; Oechsner, Markus; Mayinger, Michael C.; Mozes, Petra; Devecka, Michal; Kessel, Kerstin K.; Combs, Stephanie E.; Wilkens, Jan J.

doi:10.1186/s13014-020-01693-2

Table 4 Treatment planning results: Dose-volume histogram parameters and coverage, conformity and homogeneity indices for VMAT, IMRT, and HT (mean ± SD); ipsilateral corresponds to the tumor site, contralateral to the opposite side of tumor location

From: Report on planning comparison of VMAT, IMRT and helical tomotherapy for the ESCALOX-trial pre-study

Volume	Para-meter	Unit	VMAT	IMRT	HT	p-value
Volume	Para-meter	Unit	VMAT	IMRT	HT	IMRT vs. HT	IMRT vs. VMAT	HT vs. VMAT
SIB77Gy	Volume	cm³ (range)	54.2 ± 35.5 Median 37.7
	D_mean	Gy	79.1 ± 0.2	79.2 ± 0.2	78.5 ± 0.7	0.048	0.3	0.018
	D_100%	Gy	72.9 ± 1.0	72.7 ± 0.7	73.6 ± 1.7	0.3	0.3	0.5
	D_98%	Gy	76.3 ± 0.2	76.3 ± 0.2	76.2 ± 1.3	0.9	0.5	0.9
	D_95%	Gy	77.0 ± 0	77.0 ± 0	77.2 ± 0.1	0.6	0.1	0.6
	D_2%	Gy	81.6 ± 0.2	81.5 ± 0.5	79.8 ± 1.0	0.015	0.9	0.013
	D_5%	Gy	81.2 ± 0.2	81.2 ± 0.5	79.6 ± 1.0	0.026	1.0	0.017
Coverage	CVF		1 ± 0.00	1 ± 0.00	0.997 ± 0.007
Conformity	HTCI		0.25 ± 0.10	0.27 ± 0.11	0.37 ± 0.03
	CN		0.25 ± 0.10	0.27 ± 0.11	0.37 ± 0.03
Homogeneity	HI		1.054 ± 0.003	1.054 ± 0.006	1.032 ± 0.012
SIB70Gy (excluding SIB77Gy)	Volume	cm³	257.4 ± 112.7 Median 220.7
	D_95%	Gy	69.5 ± 0.2	69.8 ± 0.3	69.1 ± 0.8	0.2	0.2	0.4
	D_5%	Gy	77.8 ± 0.2	76.9 ± 0.6	76.7 ± 0.4	0.1	0.6	0.044
Coverage	CVF		0.995 ± 0.002	0.997 ± 0.002	0.995 ± 0.005
Conformity	HTCI		0.759 ± 0.026	0.773 ± 0.032	0.827 ± 0.031
	CN		0.754 ± 0.024	0.769 ± 0.032	0.823 ± 0.032
Homogeneity	HI		1.145 ± 0.01	1.142 ± 0.008	1.141 ± 0.015
SIB56Gy (excluding SIB70Gy)	Volume	cm³ (range)	691.9 ± 181.2 Median 653.5
	D_95%	Gy	55.4 ± 0.2	55.3 ± 0.4	55.4 ± 0.5	1.0	0.5	0.4
	D_5%	Gy	69.3 ± 0.3	68.9 ± 0.8	67.5 ± 0.8	0.5	0.1	0.015
Coverage	CVF		0.986 ± 0.004	0.985 ± 0.004	0.983 ± 0.005
Conformity	HTCI		0.747 ± 0.024	0.731 ± 0.027	0.728 ± 0.031
	CN		0.739 ± 0.023	0.723 ± 0.029	0.719 ± 0.031
Homogeneity	HI		1.391 ± 0.018	1.384 ± 0.018	1.381 ± 0.020
Organs at risk
Parotid Glands both	COIN		0.606 ± 0.040	0.593 ± 0.032	0.603 ± 0.065
ipsilateral	D_mean	Gy	32.8 ± 4.8	33.1 ± 4.4	31.1 ± 4.0	0.046	0.345	0.043
	Volume	cm³	30.4 ± 6.0
	COIN		0.555 ± 0.047	0.548 ± 0.040	0.546 ± 0.073	0.917	0.345	0.753
Contralateral	D_mean	Gy	26.3 ± 3.9	26.2 ± 3.6	22.6 ± 5.5	0.116	0.173	0.043
	Volume	cm³	26.9 ± 5.5
	COIN		0.665 ± 0.043	0.647 ± 0.040	0.664 ± 0.063	0.345	0.028	0.917
Spinal cord + 5 mm	D_max	Gy	50.5 ± 1.4	51.9 ± 1.7	45.7 ± 7.4
Brainstem	D_max	Gy	27.4 ± 7.45	29.07 ± 1.9	25.94 ± 5.9	0.1	0.1	0.037
Larynx	D_mean	Gy	45.2 ± 6.1	44.7 ± 5.8	43.3 ± 8.7
Plexus brachialis Ipsilateral	D_2%	Gy	58.5 ± 0.4	58.0 ± 0.9	57.6 ± 1.6	0.345	0.345	0.138
	COIN		0.306 ± 0.159	0.398 ± 0.433	0.505 ± 0.172	0.116	0.075	0.028
Plexus brachialis contralateral	D_2%	Gy	58.5 ± 0.3	58.1 ± 0.3	57.9 ± 1.4	0.463	0.046	0.138
	COIN		0.279 ± 0.141	0.355 ± 0.155	0.535 ± 0.178	0.028	0.028	0.028
Mandibula	D_mean	Gy	46.0 ± 7.2	48.7 ± 6.1	44.2 ± 7.7	0.014	0.025	0.1
	D_2%	Gy	70.7 ± 3.3	71.2 ± 2.6	71.9 ± 2.5	0.2	0.6	0.2

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