Table 3 Prognostic factors for ARS by univariate analysis
Variable | No. of patients | Survival rate, % | MST, mo (95% CI) | p Value | ||
|---|---|---|---|---|---|---|
6-m | 12-m | 24-m | ||||
Sex | 0.795 | |||||
Male | 206 | 81.8 | 50.8 | 21.8 | 12 (10.250–13.750) | |
Female | 46 | 82.6 | 49.1 | 21.8 | 11 (7.202–14.798) | |
Re-RT age | 0.316 | |||||
≤ 60 | 85 | 83.3 | 54.8 | 26.9 | 16 (12.706–19.294) | |
> 60 | 167 | 81.2 | 48.3 | 19.1 | 12 (9.958–14.042) | |
Alcohol abuse | 0.687 | |||||
Yes | 108 | 82.2 | 48.2 | 19.3 | 12 (9.679–14.321) | |
No | 144 | 81.7 | 52.3 | 23.8 | 13 (10.172–15.828) | |
Smoking | 0.683 | |||||
Yes | 122 | 81.0 | 48.2 | 19.9 | 12 (10.182–13.872) | |
No | 130 | 82.8 | 52.7 | 23.6 | 13 (9.675–16.325) | |
Primary tumor location | 0.773 | |||||
Upper | 72 | 83.3 | 51.4 | 17.2 | 13 (8.857–17.143) | |
Middle/lower | 180 | 81.3 | 50.1 | 23.6 | 13 (11.044–14.956) | |
Length (cm) | 0.573 | |||||
≤ 4 | 152 | 86.0 | 51.5 | 23.2 | 13 (10.043–15.957) | |
> 4 to ≤ 6 | 71 | 76.1 | 45.7 | 16.4 | 12 (9.349–14.651) | |
> 6 | 29 | 75.0 | 51.7 | 27.3 | 14 (10.111–17.889) | |
Tumor differentiation (n, %) | 0.647 | |||||
Higher | 36 | 77.1 | 51.4 | 31.3 | 17 (9.200–24.800) | |
Middle | 143 | 84.4 | 49.7 | 18.3 | 12 (10.019–13.981) | |
Lower | 73 | 79.4 | 51.5 | 23.7 | 13 (9.684–16.316) | |
Failure patterns | 0.026 | |||||
Primary failure | 93 | 82.1 | 50.5 | 14.7 | 13 (9.216–16.784) | |
Regional lymph node recurrence | 106 | 90.6 | 59.5 | 29.5 | 15 (12.118–17.882) | |
Combined | 53 | 61.8 | 29.8 | 11.5 | 9 (6.127–11.873) | |
Initial treatment | 0.173 | |||||
CRT | 167 | 82.2 | 56.0 | 28.8 | 16 (12.311–19.689) | |
Surgery | 85 | 81.8 | 47.7 | 18.8 | 12 (9.960–14.040) | |
Initial stage | 0.966 | |||||
I–II | 117 | 83.6 | 51.7 | 19.4 | 14 (11.386–16.614) | |
III–Iva | 135 | 80.4 | 49.4 | 23.7 | 12 (9.942–14.058) | |
RFI time | 0.024 | |||||
≤ 12 months | 76 | 77.6 | 38.9 | 13.8 | 11 (9.600–12.400) | |
> 12 months | 176 | 83.8 | 55.6 | 25.4 | 14 (11.622–16.378) | |
Chemotherapy | 0.001 | |||||
Yes | 198 | 85.2 | 55.8 | 24.4 | 14 (11.739–16.261) | |
No | 54 | 94.4 | 30.5 | 11.9 | 8 (6.602–9.398) | |
Salvage radiation dose (BED10) | 0.326 | |||||
≤ 60 Gy | 133 | 80.9 | 45.0 | 23 | 12 (10.440–13.560) | |
> 60 Gy | 119 | 83.1 | 56.6 | 20.7 | 14 (11.791–16.209) | |
Total radiation dose (BED10) | 0.545 | |||||
≤ 131.5 Gy | 130 | 79.5 | 46.7 | 24.9 | 12 (9.115–14.885) | |
> 131.5 Gy | 122 | 84.4 | 54.5 | 18.5 | 13 (10.159–15.841) | |
Esophageal stenosis | 0.070 | |||||
Yes | 102 | 82.0 | 50.4 | 14.6 | 13 (10.599–15.401) | |
No | 150 | 81.9 | 50.6 | 26.5 | 13 (10.200–15.800) | |
Pain in the chest or/and back | 0.761 | |||||
Yes | 25 | 80.0 | 42.5 | 18.9 | 11 (6.314–15.686) | |
No | 227 | 82.1 | 51.4 | 22.1 | 13 (11.117–14.883) | |
Fat space between tumor and adjacent tissue disappeared | 0.121 | |||||
Yes | 64 | 82.6 | 46.1 | 12.9 | 12 (9.416–14.584) | |
No | 188 | 81.7 | 52.1 | 24.7 | 13 (10.394–15.606) | |
BMI | 0.269 | |||||
≤ 20 | 74 | 82.2 | 46.0 | 17 | 12 (9.745–14.255) | |
> 20 | 178 | 81.8 | 52.4 | 23.8 | 14 (11.483–16.517) | |
Hemoglobin (g/L) | 0.159 | |||||
≤ 12 | 95 | 80.6 | 46.8 | 18.7 | 12 (9.446–15.554) | |
> 12 | 157 | 82.7 | 52.7 | 23.7 | 13 (10.200–15.800) | |
Albumin (g/L) | 0.281 | |||||
≤ 40 | 87 | 83.7 | 48.0 | 17.9 | 12 (10.095–13.905) | |
> 40 | 165 | 80.9 | 51.8 | 23.8 | 13 (10.195–15.805) | |