Feasibility study: spot-scanning proton arc therapy (SPArc) for left-sided whole breast radiotherapy

Radiation Oncology

Table 1 OARs, corresponding clinical endpoints, and NTCP models used in the present work

OAR	Clinical endpoint	References	Model
Heart	Mortality	Gagliardi et al. [35, 39]	Poission LQ model:D50 = 52.4 Gy,γ = 1.28,s = 1
LAD	Mortality	Gagliardi et al. [35, 39]	Poission LQ model:D50 = 52.4 Gy,γ = 1.28,s = 1
Left lung	Radiation pneumonitis	Seppenwoolde et al. [37, 38]	LKB model: TD50 = 30.8 Gy, m = 0.37, n = 0.99
Skin	Severe acute toxicity	Pastore et al. [36, 38]	LKB model: TD50 = 39 Gy, m = 0.14, n = 0.38

LKB model: \(\mathrm{NTCP}=\frac{1}{\sqrt{2\pi }}{\int }_{-\infty }^{t}{e}^{{-t}^{2}/2}dt\), t = (D-TD₅₀(V))/(m·TD₅₀(V)), TD₅₀(V) = TD₅₀(1)/Vⁿ
Poission LQ model: \(NTCP\)=\({\left\{1-\prod_{i=1}^{n}{\left[1-P{({D}_{i})}^{s}\right]}^{{V}_{i}/V}\right\}}^{1/s}\), \(P\)(\({D}_{i}\)) = \({2}^{-exp\left\{e\gamma (1-{D}_{i}/{D}_{50})\right\}}\)

ISSN: 1748-717X