Cardiac radiation dose predicts survival in esophageal squamous cell carcinoma treated by definitive concurrent chemotherapy and intensity modulated radiotherapy

Table 3 Multivariate analysis for heart dose-volume parameters and overall survival under consideration of different lung parameters

Heart	Mean lung dose	Lung V5	Lung V10	Lung V20	Lung V30	Lung V40
Heart	HR (95% CI) P value
Mean dose	1.000	1.000	1.000	1.000	1.000	1.000
	(1.000–1.000)	(1.000–1.000)	(1.000–1.000)	(1.000–1.000)	(1.000–1.000)	(1.000–1.000)
	0.052	0.068	0.034	0.035	0.022	0.020
V5	1.011	1.011	1.012	1.012	1.012	1.012
	(1.001–1.020)	(1.001–1.021)	(1.002–1.022)	(1.002–1.021)	(1.003–1.022)	(1.003–1.022)
	0.029	0.032	0.016	0.016	0.010	0.009
V10	1.010	1.010	1.011	1.011	1.011	1.012
	(1.001–1.019)	(1.001–1.020)	(1.002–1.020)	(1.002–1.020)	(1.003–1.020)	(1.003–1.021)
	0.032	0.039	0.020	0.020	0.012	0.010
V20	1.010	1.010	1.011	1.011	1.011	1.012
	(1.001–1.019)	(1.001–1.020)	(1.002–1.020)	(1.002–1.020)	(1.003–1.020)	(1.003–1.021)
	0.029	0.038	0.019	0.020	0.011	0.009
V30	1.010	1.009	1.011	1.010	1.011	1.011
	(1.000–1.020)	(0.999–1.020)	(1.001–1.020)	(1.001–1.020)	(1.002–1.021)	(1.002–1.021)
	0.048	0.068	0.035	0.036	0.021	0.016
V40	1.011	1.011	1.012	1.012	1.012	1.013
	(1.001–1.022)	(1.000–1.022)	(1.001–1.023)	(1.001–1.022)	(1.002–1.023)	(1.002–1.023)
	0.034	0.053	0.028	0.028	0.019	0.017
V50	1.014	1.012	1.014	1.014	1.014	1.014
	(1.000–1.027)	(0.999–1.026)	(1.001–1.028)	(1.001–1.028)	(1.001–1.028)	(1.001–1.028)
	0.046	0.077	0.042	0.038	0.035	0.040

ISSN: 1748-717X