Fig. 7

One-way analysis of variance for inflammatory factor expression showed the changes among the different groups after irradiation and resolvin E1-pretreatment. ^*, P ≤ 0.05; ^**, P ≤ 0.01; a. The expression level changes of IL-2 among the different groups. The expression level of IL-2 in the modiolus was significantly decreased on days 7 and 14 after irradiation (compared between the Sham/WT and Rad groups). b. The expression level changes of IL-6 among the different groups. The expression levels of IL-6 in the basal membrane and vestibule were significantly increased on days 7 and 14 after irradiation (compared between the Sham/WT and Rad groups). c. The expression level changes of TNF-α among the different groups. The expression levels of TNF-α in the modiolus and vestibule were significantly increased on day 7 after irradiation (compared between the Sham/WT and Rad groups), and a similar significant change was observed only in the modiolus on day 14 after irradiation (compared between the Sham/WT and Rad groups). d and e. The expression level changes of IL-10 and IFN-γ among the different groups. The expression of IL-10 and IFN-γ did not significantly change among the different groups. All these significant changes after irradiation could be ameliorated by resolvin E1 (RvE1) pretreatment (compared between the Rad and Rad+RvE1 groups)