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Fig. 1 | Radiation Oncology

Fig. 1

From: A unique radioprotective effect of resolvin E1 reduces irradiation-induced damage to the inner ear by inhibiting the inflammatory response

Fig. 1

One-way analysis of variance for hearing threshold and relative balance ability showed the changes among the different groups after irradiation and resolvin E1-pretreatment. *, P ≤ 0.05; **, P ≤ 0.01; a. Hearing changes after irradiation and resolvin E1-pretreatment. Irradiation-induced hearing loss, which was obvious on days 7 and 14 after irradiation; resolvin E1 (RvE1) mitigated the irradiation-induced hearing loss. The red asterisk indicates a comparison between the Sham/WT and Rad groups. The black asterisk indicates a comparison between the Rad and Rad+RvE1 groups. b. Relative balance ability changes after irradiation and resolvin E1-pretreatment. The relative balance ability in Sham/WT, RvE1, Rad and Rad+RvE1 groups were respectively 1.154 ± 0.171, 1.149 ± 0.133, 0.869 ± 0.085, and 1.039 ± 0.115 on day 7 and 1.137 ± 0.151, 1.134 ± 0.161, 0.927 ± 0.066, and 1.048 ± 0.094 on day 14. Irradiation induced damage in relative balance ability (compared between the Sham/WT and Rad groups) on days 7 and 14 after irradiation (P = 0.0045 and P = 0.0107), and RvE1 mitigated this damage (comparison between the Rad and Rad+RvE1 groups, P = 0.0155 on day 7 and P = 0,0270 on day 14)

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