Study | CRT regimen | Leukopenia (%) | Neutropenia (%) | Thrombocytopenia (%) | Anemia (%) | Radiation pneumonitis (%) | Radiation esophagitis (%) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
All | ≥3 | All | ≥3 | All | ≥3 | All | ≥3 | All | ≥3 | All | ≥3 | ||
RTOG 9410 [5] | RT + VP | NR | 83.9 | NR | NR | NR | 9.3 | NR | 11.8 | NR | 12.5 | NR | 22.2 |
RT + EP | NR | 68.4 | NR | NR | NR | 16.0 | NR | 18.8 | NR | 16.9 | NR | 44.9 | |
RTOG 0617 [41] | LDR + PC | 61.1 | 32.1 | 40.4 | 23.8 | 37.7 | 6.6 | 58.9 | 7.9 | 10.0 | 4.6 | 46.4 | 7.3 |
HDR + PC | 57.0 | 30.8 | 46.7 | 26.2 | 41.1 | 7.5 | 58.9 | 8.0 | 12.1 | 1.0 | 54.2 | 15.0 | |
LDR + PC + Cet | 51.8 | 30.7 | 54.7 | 40.9 | 35.8 | 8.0 | 63.4 | 11.6 | 12.4 | 7.3 | 43.8 | 6.6 | |
HDR + PC + Cet | 54.0 | 37.0 | 59.0 | 46.9 | 44.0 | 16.0 | 51.0 | 6.0 | 17.0 | 6.0 | 54.0 | 19.0 | |
PROCLAIM [42] | RT + PP | 36.7 | 22.6 | 42.8 | 24.4 | 55.0 | 40.3 | 40.3 | 8.8 | 17.0 | 1.8 | 48.1 | 15.5 |
RT + EP | 40.8 | 30.1 | 54.8 | 44.5 | 85.0 | 29.0 | 45.6 | 13.6 | 10.7 | 2.6 | 50.7 | 20.6 | |
CAMS [43] | RT + EP RT + PC | 95.8 92.7 | 30.5 20.7 | NR NR | NR NR | 12.7 5.2 | 0 0 | 24.2 13.5 | 0 0 | 76.8 72.9 | 7.4 8.3 | 87.0 84.0 | 20.0 6.3 |
WJOG5008L [44] | RT + SP | 96.3 | 40.7 | 88.9 | 33.3 | 42.6 | 9.3 | 79.6 | 25.5 | 24.1 | 9.3 | 66.7 | 3.7 |
RT + VP | 100 | 79.6 | 94.4 | 75.9 | 22.0 | 3.7 | 88.9 | 27.8 | 20.4 | 7.4 | 74.1 | 0.0 |