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Table 3 Impact of TTI on locoregional control and index cancer-specific hazard (N = 197 patients with 207 tumors): a multivariate analysis

From: Impact of delays in radiotherapy of head and neck cancer on outcome

Parameter

HR

95% CI

P-value

Locoregional control

 TNM (III vs. I-II)

0.843

0.369–1.925

0.685

 TNM (IV vs. I-II)

2.320

1.211–4.444

0.011

 Age

0.976

0.950–1.002

0.075

 TTI

1.012

0.998–1.027

0.094

 Gender

0.501

0.201–1.249

0.138

 Therapy (CCT vs. RT)

0.768

0.444–1.328

0.344

Cause specific hazard

 TNM (III vs. I-II)

3.203

1.286–7.976

0.012

 TNM (IV vs. I-II)

13.223

6.007–29.108

< 0.001

 Age

0.985

0.965–1.005

0.133

 TTI

1.001

0.990–1.012

0.844

 Gender

0.907

0.529–1.556

0.724

 Therapy (CCT vs. RT)

0.534

0.369–0.774

0.001

  1. CI Confidence interval; TTI Time to treatment intervention;
  2. CCT Concurrent chemoradiotherapy; RT Radiotherapy