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Table 3 Univariate and multivariate analysis for radiation necrosis

From: Immune checkpoint inhibition in patients treated with stereotactic radiation for brain metastases

Covariate

HR (95% CI)

P-value

Univariate

 Surgical resection

1.92 (0.57–6.46)

0.29

 Tumor size ≤2 cm

0.28 (0.13–0.63)

0.002

 Concurrent systemic therapy

1.03 (0.41–2.59)

0.94

 Location of metastasis

1.23 (0.46–3.29)

0.68

 Single vs Multi-fraction SRT

1.24 (0.52–2.96)

0.64

 Age

0.99 (0.95–1.02)

0.47

 Recent Immunotherapy

0.50 (0.17–1.45)

0.20

 Prior WBRT

1.89 (0.86–4.15)

0.11

Multivariate

 Recent immunotherapy

0.98 (0.28–3.51)

0.98

 Prior WBRT

1.55 (0.56–4.31)

0.40

 Tumor size ≤2 cm

0.24 (0.09–0.64)

0.004