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Table 3 Univariate and multivariate analysis for radiation necrosis

From: Immune checkpoint inhibition in patients treated with stereotactic radiation for brain metastases

Covariate HR (95% CI) P-value
Univariate
 Surgical resection 1.92 (0.57–6.46) 0.29
 Tumor size ≤2 cm 0.28 (0.13–0.63) 0.002
 Concurrent systemic therapy 1.03 (0.41–2.59) 0.94
 Location of metastasis 1.23 (0.46–3.29) 0.68
 Single vs Multi-fraction SRT 1.24 (0.52–2.96) 0.64
 Age 0.99 (0.95–1.02) 0.47
 Recent Immunotherapy 0.50 (0.17–1.45) 0.20
 Prior WBRT 1.89 (0.86–4.15) 0.11
Multivariate
 Recent immunotherapy 0.98 (0.28–3.51) 0.98
 Prior WBRT 1.55 (0.56–4.31) 0.40
 Tumor size ≤2 cm 0.24 (0.09–0.64) 0.004