| Variable | Subgroup | n | Overall estimate of meta-regression | |||
---|---|---|---|---|---|---|---|
Sensitivity(95% CI) | p | Specificity(95% CI) | p | ||||
ASL | Region | China | 14 | 0.89(0.84,0.94) | 0.01 | 0.89(0.83,0.95) | 0.71 |
others | 5 | 0.86(0.77,0.95) | 0.94(0.88,1.00) | ||||
Year | 2008–2014 | 8 | 0.87(0.80,0.93) | 0.00 | 0.88(0.80,0.96) | 0.01 | |
2015–2019 | 11 | 0.89(0.83,0.95) | 0.92(0.87,0.98) | ||||
Number of patients | ≤40 | 10 | 0.90(0.84,0.95) | 0.00 | 0.93(0.87,0.99) | 0.01 | |
>40 | 9 | 0.87(0.81,0.93) | 0.88(0.81,0.95) | ||||
Field strength | 1.5 T | 2 | 0.90(0.79,1.00) | 0.21 | 0.96(0.90,1.00) | 0.13 | |
3.0 T | 17 | 0.88(0.83,0.93) | 0.89(0.84,0.94) | ||||
QUADAS-2 score | ≤10 | 7 | 0.93(0.89,0.98) | 0.00 | 0.94(0.89,1.00) | 0.01 | |
>10 | 12 | 0.84(0.79,0.90) | 0.88(0.81,0.94) | ||||
DSC-MRI | Region | China | 4 | 0.94(0.83,1.00) | 0.77 | 0.88(0.74,1.00) | 0.14 |
others | 15 | 0.91(0.84,0.99) | 0.80(0.72,0.88) | ||||
Year | 2006–2014 | 10 | 0.95(0.89,1.00) | 0.07 | 0.80(0.69,0.90) | 0.20 | |
2015–2017 | 9 | 0.87(0.74,0.99) | 0.83(0.73,0.93) | ||||
Age | ≤45 | 9 | 0.94(0.87,1.00) | 0.31 | 0.85(0.75,0.95) | 0.03 | |
>45 | 10 | 0.90(0.80,1.00) | 0.79(0.68,0.89) | ||||
Number of patients | ≤40 | 10 | 0.95(0.88,1.00) | 0.33 | 0.89(0.82,0.95) | 0.56 | |
>40 | 9 | 0.89(0.79,1.00) | 0.72(0.62,0.83) | ||||
Field strength | 1.5 T | 4 | 0.98(0.93,1.00) | 0.23 | 0.76(0.60,0.92) | 0.00 | |
3.0 T | 15 | 0.90(0.82,0.98) | 0.83(0.75,0.91) | ||||
QUADAS-2 score | ≤10 | 10 | 0.94(0.88,1.00) | 0.14 | 0.86(0.77,0.95) | 0.01 | |
>10 | 9 | 0.88(0.77,0.99) | 0.77(0.66,0.88) | ||||
DKI | Region | China | 9 | 0.89(0.83,0.95) | 0.01 | 0.89(0.82,0.95) | 0.01 |
others | 7 | 0.86(0.77,0.94) | 0.81(0.69,0.92) | ||||
Year | 2010–2015 | 4 | 0.85(0.75,0.95) | 0.14 | 0.89(0.79,0.99) | 0.06 | |
2016–2019 | 12 | 0.89(0.84,0.94) | 0.85(0.77,0.96) | ||||
Age | ≤48 | 9 | 0.85(0.78,0.92) | 0.14 | 0.87(0.79,0.94) | 0.02 | |
>48 | 7 | 0.91(0.85,0.97) | 0.84(0.75,0.93) | ||||
Number of patients | ≤40 | 11 | 0.83(0.77,0.89) | 0.32 | 0.88(0.81,0.94) | 0.00 | |
>40 | 5 | 0.93(0.89,0.98) | 0.80(0.70,0.90) | ||||
QUADAS-2 score | ≤10 | 10 | 0.84(0.78,0.91) | 0.18 | 0.87(0.80,0.94) | 0.02 | |
>10 | 6 | 0.92(0.87,0.97) | 0.83(0.72,0.93) |