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Table 3 Meta-regression

From: The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the grading of cerebral gliomas: a meta-analysis

 

Variable

Subgroup

n

Overall estimate of meta-regression

Sensitivity(95% CI)

p

Specificity(95% CI)

p

ASL

Region

China

14

0.89(0.84,0.94)

0.01

0.89(0.83,0.95)

0.71

others

5

0.86(0.77,0.95)

0.94(0.88,1.00)

Year

2008–2014

8

0.87(0.80,0.93)

0.00

0.88(0.80,0.96)

0.01

2015–2019

11

0.89(0.83,0.95)

0.92(0.87,0.98)

Number of patients

≤40

10

0.90(0.84,0.95)

0.00

0.93(0.87,0.99)

0.01

>40

9

0.87(0.81,0.93)

0.88(0.81,0.95)

Field strength

1.5 T

2

0.90(0.79,1.00)

0.21

0.96(0.90,1.00)

0.13

3.0 T

17

0.88(0.83,0.93)

0.89(0.84,0.94)

QUADAS-2

score

≤10

7

0.93(0.89,0.98)

0.00

0.94(0.89,1.00)

0.01

>10

12

0.84(0.79,0.90)

0.88(0.81,0.94)

DSC-MRI

Region

China

4

0.94(0.83,1.00)

0.77

0.88(0.74,1.00)

0.14

others

15

0.91(0.84,0.99)

0.80(0.72,0.88)

Year

2006–2014

10

0.95(0.89,1.00)

0.07

0.80(0.69,0.90)

0.20

2015–2017

9

0.87(0.74,0.99)

0.83(0.73,0.93)

Age

≤45

9

0.94(0.87,1.00)

0.31

0.85(0.75,0.95)

0.03

>45

10

0.90(0.80,1.00)

0.79(0.68,0.89)

Number of patients

≤40

10

0.95(0.88,1.00)

0.33

0.89(0.82,0.95)

0.56

>40

9

0.89(0.79,1.00)

0.72(0.62,0.83)

Field strength

1.5 T

4

0.98(0.93,1.00)

0.23

0.76(0.60,0.92)

0.00

3.0 T

15

0.90(0.82,0.98)

0.83(0.75,0.91)

QUADAS-2

score

≤10

10

0.94(0.88,1.00)

0.14

0.86(0.77,0.95)

0.01

>10

9

0.88(0.77,0.99)

0.77(0.66,0.88)

DKI

Region

China

9

0.89(0.83,0.95)

0.01

0.89(0.82,0.95)

0.01

others

7

0.86(0.77,0.94)

0.81(0.69,0.92)

Year

2010–2015

4

0.85(0.75,0.95)

0.14

0.89(0.79,0.99)

0.06

2016–2019

12

0.89(0.84,0.94)

0.85(0.77,0.96)

Age

≤48

9

0.85(0.78,0.92)

0.14

0.87(0.79,0.94)

0.02

>48

7

0.91(0.85,0.97)

0.84(0.75,0.93)

Number of patients

≤40

11

0.83(0.77,0.89)

0.32

0.88(0.81,0.94)

0.00

>40

5

0.93(0.89,0.98)

0.80(0.70,0.90)

QUADAS-2

score

≤10

10

0.84(0.78,0.91)

0.18

0.87(0.80,0.94)

0.02

>10

6

0.92(0.87,0.97)

0.83(0.72,0.93)