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Table 3 Relative differences (%) in dosimetric parameters of the GTV, PTV and 2 cm ring around the PTV (‘Ring’), between the adapted plans and the reference plans. All mean changes larger than 1% are marked in bold. GTV: Gross Tumor Volume, PTV: Planning Target Volume, SD: Standard Deviation

From: Treatment plan quality during online adaptive re-planning

  ALL Abdomen Liver Liver (non-SBRT) Lung Prostate Prostate (non-SBRT) Pelvis
GTV
 Dmean
  Median [range] 0.14 [−9.0–4.7] −0.11 [−9.0–4.7] 0.23 [−2.5–3.4] − 0.23 [− 0.98–0.56] 0.46 [− 1.9–4.6] 0.19 [− 1.2–2.3] − 0.44 [− 1.1–1.3] 0.18 [− 2.5–1.5]
  Mean ± SD 0.06 ± 1.5 − 0.26 ± 2.1 0.35 ± 1.4 − 0.17 ± 0.44 0.42 ± 1.3 0.40 ± 0.79 − 0.21 ± 0.70 0.00 ± 1.1
  P-value 0.04 0.56 0.21 0.31 0.06 0.005 0.16 0.61
 D95%
  Median [range] − 0.11 [− 25.8–31.3] −0.35 [− 25.8–31.3] 0.44 [− 8.7–5.8] − 0.46 [− 1.2–0.78] 0.20 [− 2.2–5.4] −0.03 [− 0.85–4.1] −0.43 [− 1.2–1.3] 0.15 [− 1.7–1.5]
  Mean ± SD − 0.09 ± 4.5 − 0.68 ± 7.4 0.42 ± 2.7 −0.34 ± 0.64 0.41 ± 1.5 0.38 ± 1.2 −0.32 ± 0.66 0.09 ± 0.72
  P-value 0.71 0.008 0.14 0.10 0.21 0.27 0.07 0.46
 D98%
  Median [range] −0.19 [− 23.7–44.7] −0.57 [− 23.7–44.7] 0.53 [−9.3–10.8] − 0.69 [− 2.7–0.92] 0.18 [− 2.1–5.4] −0.04 [− 1.3–6.3] −0.43 [− 1.2–1.1] 0.03 [− 2.4–1.6]
  Mean ± SD 0.04 ± 5.3 −0.40 ± 8.6 0.47 ± 4.0 −0.61 ± 1.0 0.48 ± 1.5 0.63 ± 1.9 −0.30 ± 0.64 −0.03 ± 0.89
  P-value 0.34 0.002 0.15 0.08 0.11 0.39 0.08 0.97
 D2%
  Median [range] 0.46 [−11.6–4.4] 0.65 [− 11.6–4.4] 0.29 [− 3.2–2.7] 0.22 [− 0.42–1.0] 0.29 [− 2.7–2.9] 0.64 [− 1.5–4.2] −0.43 [− 1.3–1.7] 0.47 [− 3.7–2.1]
  Mean ± SD 0.40 ± 1.5 0.42 ± 2.0 0.36 ± 1.3 0.30 ± 0.41 0.37 ± 1.46 0.85 ± 1.0 − 0.02 ± 0.90 0.07 ± 1.4
  P-value < 0.0001 0.007 0.26 0.03 0.10 < 0.0001 0.95 0.30
PTV
 Dmean
  Median [range] 0.08 [−8.6–5.4] − 0.11 [− 8.6–5.4] 0.23 [− 5.0–2.2] −0.17 [− 1.3–0.23] 0.31 [− 2.4–3.2] 0.19 [− 1.2–1.3] −0.17 [− 0.65–0.00] 0.24 [− 2.1–1.9]
  Mean ± SD 0.01 ± 1.5 −0.29 ± 2.1 0.16 ± 1.6 −0.26 ± 0.57 0.40 ± 1.3 0.27 ± 0.46 −0.22 ± 0.25 0.09 ± 1.1
  P-value 0.02 0.54 0.13 0.12 0.05 < 0.0001 0.007 0.26
 D95%
  Median [range] 0.00 [− 26.4–13.4] −0.26 [− 12.9–18.4] 0.18 [− 26.4–6.2] − 0.34 [− 5.1–0.24] −0.02 [− 2.0–4.4] 0.03 [− 0.86–1.2] −0.05 [− 0.89–1.1] 0.36 [− 1.3–2.6]
  Mean ± SD −0.24 ± 3.6 −0.55 ± 5.2 −0.56 ± 5.8 − 1.1 ± 1.7 0.08 ± 1.2 0.10 ± 0.44 − 0.05 ± 0.55 0.37 ± 0.96
  P-value 0.95 0.12 0.33 0.02 0.98 0.26 0.70 0.06
 D98%
  Median [range] −0.04 [−31.6–25.4] −0.19 [− 18.9–25.4] −0.14 [− 31.6–24.4] −0.33 [− 29.7–0.21] −0.18[− 21.0–5.5] 0.18[− 2.4–5.9] −0.16[− 2.0–1.4] 0.16[− 2.6–2.2]
  Mean ± SD −0.25 ± 5.4 −0.18 ± 5.7 0.37 ± 8.9 −5.4 ± 10.8 −0.57 ± 3.6 0.74 ± 1.9 −0.15 ± 0.77 0.40 ± 1.17
  P-value 0.46 0.21 0.95 0.03 0.18 0.04 0.41 0.09
 D2%
  Median [range] 0.26[−43.6–3.9] 0.32[− 3.3–3.6] 0.25[− 43.6–3.1] 0.10[− 0.23–0.86] 0.38[− 2.5–3.9] 0.51[−1.6–3.7] −0.29[− 1.4–0.96] 0.31[−3.7–2.1]
  Mean ± SD 0.14 ± 3.1 0.37 ± 1.4 −1.3 ± 8.7 0.15 ± 0.30 0.41 ± 1.5 0.62 ± 0.91 − 0.10 ± 0.67 −0.11 ± 1.5
  P-value < 0.0001 0.04 0.21 0.17 0.15 < 0.0001 0.80 0.71
Ring
 Dmean
  Median [range] 0.80[−15.8–13.1] 1.0[−7.2–8.4] 1.6[− 4.5–8.1] −0.28[− 4.7–2.7] 0.80[−4.2–7.8] − 0.17[− 15.8–6.8] 0.00[− 10.0–2.7] 1.5[− 1.9–13.1]
  Mean ± SD 1.0 ± 3.6 1.4 ± 3.2 1.6 ± 3.4 −0.14 ± 2.2 1.8 ± 2.9 −0.89 ± 5.3 −0.51 ± 2.7 2.5 ± 3.4
  P-value < 0.0001 0.0002 0.05 0.89 0.01 0.89 0.85 0.001
 D5%
  Median [range] 0.56 [−10.5–6.8] 0.72[− 4.3–6.0] 0.21[− 2.0–6.8] 0.00[−1.7–0.86] 1.6[−3.5–4.9] − 0.10[− 10.5–3.0] 0.34[− 1.1–1.9] 1.3[− 0.24–5.8]
  Mean ± SD 0.64 ± 2.1 0.71 ± 1.5 0.90 ± 2.1 − 0.07 ± 0.79 1.3 ± 2.0 −0.70 ± 3.3 0.35 ± 0.78 1.6 ± 1.4
  P-value < 0.0001 < 0.0001 0.11 0.84 0.002 0.86 0.11 < 0.0001