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Fig. 1 | Radiation Oncology

Fig. 1

From: Oncometabolites and the response to radiotherapy

Fig. 1

Schematic representation of how oncometabolites inhibit αKG-dependent dioxygenases (αKGDDs). 2-HG, succinate and fumarate are antagonists to αKG and broadly inhibit αKG-dependent dioxygenases (αKGDDs). αKGDDs use O2 and αKG as co-factors to perform a range of oxidation reactions gaining succinate, CO2 and hydroxylated target molecule. αKG = α-Ketoglutarate, L/D-2-HG = L/D-2-hydroxyglutarate, R = target molecule

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