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Table 4 Comparison between the present study and the previous studies of LAHCC

From: Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma

Reference

Year

n

Treatment Method

OS

Kudo M, et al. [3]

2018

250

Lenvatinib

Median OS: 11.5 months

Bruix J, et al. [4]

2012

108

Sorafenib

Median OS: 8.1 months

Yoon SM, et al. [5])

2018

45

Sorafenib

Median OS: 9.9 months

Kodama K, et al. [21]

2018

36

Sorafenib

Median OS: 5.3 months

Kodama K, et al. [21]

2018

36

HAIC with RT

Median OS: 9.9 months

Yoon SM, et al. [5]

2018

45

TACE with RT

Median OS: 12.7 months

Zhang X, et al.a [22]

2017

21–604

Sorafenib

Median OS: 7.0–13.0 months

Kudo M, et al. [15]

2019

1101

Surgery

3y-OS: 40%

Liu PH, et al. [23]

2014

247

Surgery

3y-OS: 68%

Shi J, et al. [24]

2010

406

Surgery

3y-OS: 13%

Komatsu S, et al. [25]

2017

19

Particle RT (proton beam therapy and C-ion RT)

Median OS: 24.6 months

Present study

 

11

C-ion RT

Median OS: 36.4 months, 3y-OS: 64%

  1. aReview article
  2. Abbreviations: C-ion RT carbon ion radiotherapy, HAIC hepatic arterial infusion chemotherapy, OS overall survival, RT radiotherapy, TACE transarterial chemoembolization, 3y-OS 3-year overall survival