Table 3 Multivariate analyses of freedom from distant metastases, locoregional control, and overall survival rates

 Early missed RT vs. RT as scheduled

1.644 (1.047–2.583)

0.031

1.422 (0.877–2.204)

0.152

1.486 (1.122–1.966)

0.006*

 Late missed RT vs. RT as scheduled

1.022 (0.710–1.472)

0.903

1.389 (1.032–1.878)

0.031

1.201 (0.978–1.474)

0.080

 Early missed RT vs. late missed RT

1.683 (1.047–2.702)

0.031

0.981 (0.608–1.582)

0.937

1.246 (0.939–1.652)

0.164

pT Stage (3/4 vs.1/2)

1.952 (1.097–3.472)

0.023

1.722 (1.083–2.930)

0.039

1.56 (1.144–2.142)

0.006*

pN Stage (2/3 vs.0/1)

3.612 (2.327–5.609)

< 0.001

1.650 (1.170–2.313)

0.007

1.805 (1.423–2.316)

< 0.001*

 (Moderately vs. Well)

1.323 (0.844–2.074)

0.223

1.203 (0.859–1.686)

0.282

1.163 (0.921–1.468)

0.205

 (Poorly vs. Well)

2.078 (1.204–3.586)

0.009

1.103 (0.690–1.764)

0.682

1.155 (0.825–1.585)

0.389

Sex (Male vs. Female)

1.078 (0.463–2.036)

0.938

0.924 (0.530–1.613)

0.781

1.079 (0.746–1.727)

0.726

Age (> 60 vs. ≤60 years)

1.082 (0.774–1.513)

0.643

0.884 (0.668–1.170)

0.390

1.500 (1.234–1.824)

< 0.001*

Chemotherapy (Yes vs. no)

1.244 (0.798–1.923)

0.335

0.950 (0.696–1.407)

0.955

1.026 (0.791–1.303)

0.915

TPT (days)

(> 85 vs. ≤85)

0.901 (0.597–1.360)

0.619

1.108 (0.775–1.584)

0.575

0.866 (0.670–1.119)

0.272

Alcohol (Yes vs. No)

1.135 (0.789–1.631)

0.496

1.224 (0.901–1.664)

0.197

1.269 (1.025–1.569)

0.028*

Betel quid (Yes vs. no)

1.406 (0.897–2.203)

0.137

1.445 (0.926–2.256)

0.105

1.168 (0.913–1.494)

0.216

Smoking (Yes vs. no)

1.484 (0.841–2.619)

0.173

0.859 (0.572–1.290)

0.463

0.916 (0.684–1.226)

0.555

Comorbidity (Yes vs. no)

1.090 (0.784–1.515)

0.609

1.040 (0.792–1.367)

0.777

1.115 (0.922–1.348)

0.260

S/RT interval

1.049 (0.659–1.669)

0.841

1.236 (0.800–1.910)

0.340

1.199 (0.913–1.575)

0.191

PET (Yes vs. no)

0.937 (0.665–1.319)

0.708

1.470 (1.048–1.063)

0.026

1.115 (0.922–1.348)

0.138