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Table 3 Multivariate analyses of freedom from distant metastases, locoregional control, and overall survival rates

From: Missed radiation therapy sessions in first three weeks predict distant metastasis and less favorable outcomes in surgically treated patients with oral cavity squamous cell carcinoma

  FFDM   LRCR   OS  
Covariate HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value
RT schedule
 Early missed RT vs. RT as scheduled 1.644 (1.047–2.583) 0.031 1.422 (0.877–2.204) 0.152 1.486 (1.122–1.966) 0.006*
 Late missed RT vs. RT as scheduled 1.022 (0.710–1.472) 0.903 1.389 (1.032–1.878) 0.031 1.201 (0.978–1.474) 0.080
 Early missed RT vs. late missed RT 1.683 (1.047–2.702) 0.031 0.981 (0.608–1.582) 0.937 1.246 (0.939–1.652) 0.164
pT Stage (3/4 vs.1/2) 1.952 (1.097–3.472) 0.023 1.722 (1.083–2.930) 0.039 1.56 (1.144–2.142) 0.006*
pN Stage (2/3 vs.0/1) 3.612 (2.327–5.609) < 0.001 1.650 (1.170–2.313) 0.007 1.805 (1.423–2.316) < 0.001*
Differentiation
 (Moderately vs. Well) 1.323 (0.844–2.074) 0.223 1.203 (0.859–1.686) 0.282 1.163 (0.921–1.468) 0.205
 (Poorly vs. Well) 2.078 (1.204–3.586) 0.009 1.103 (0.690–1.764) 0.682 1.155 (0.825–1.585) 0.389
Sex (Male vs. Female) 1.078 (0.463–2.036) 0.938 0.924 (0.530–1.613) 0.781 1.079 (0.746–1.727) 0.726
Age (> 60 vs. ≤60 years) 1.082 (0.774–1.513) 0.643 0.884 (0.668–1.170) 0.390 1.500 (1.234–1.824) < 0.001*
Chemotherapy (Yes vs. no) 1.244 (0.798–1.923) 0.335 0.950 (0.696–1.407) 0.955 1.026 (0.791–1.303) 0.915
TPT (days)
(> 85 vs. ≤85)
0.901 (0.597–1.360) 0.619 1.108 (0.775–1.584) 0.575 0.866 (0.670–1.119) 0.272
Alcohol (Yes vs. No) 1.135 (0.789–1.631) 0.496 1.224 (0.901–1.664) 0.197 1.269 (1.025–1.569) 0.028*
Betel quid (Yes vs. no) 1.406 (0.897–2.203) 0.137 1.445 (0.926–2.256) 0.105 1.168 (0.913–1.494) 0.216
Smoking (Yes vs. no) 1.484 (0.841–2.619) 0.173 0.859 (0.572–1.290) 0.463 0.916 (0.684–1.226) 0.555
Comorbidity (Yes vs. no) 1.090 (0.784–1.515) 0.609 1.040 (0.792–1.367) 0.777 1.115 (0.922–1.348) 0.260
S/RT interval 1.049 (0.659–1.669) 0.841 1.236 (0.800–1.910) 0.340 1.199 (0.913–1.575) 0.191
PET (Yes vs. no) 0.937 (0.665–1.319) 0.708 1.470 (1.048–1.063) 0.026 1.115 (0.922–1.348) 0.138
  1. Abbreviations: FFDM freedom from distant metastases, LRC locoregional control, OS overall survival, RT radiotherapy, TPT total package time, S surgery, PET positron emission tomography, HR hazard ratio, CI confidence interval. *Denotes statistically significant p values