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Table 2 Univariate analyses of freedom from distant metastases, locoregional control, and overall survival rates

From: Missed radiation therapy sessions in first three weeks predict distant metastasis and less favorable outcomes in surgically treated patients with oral cavity squamous cell carcinoma

  FFDM   LRC   OS  
Covariate HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value
RT schedule
 Early missed RT vs. RT as scheduled 1.470 (0.946–2.283) 0.086 1.383 (0.920–2.079) 0.118 1.385 (1.052–1.821) 0.020*
 Late missed RT vs. RT as scheduled 0.916 (0.641–1.311) 0.632 1.453 (1.091–1.935) 0.011 1.177 (0.962–1.439) 0.112
 Early missed RT vs. late missed RT 1.602 (1.004–2.564) 0.048 1.050 (0.700–1.576) 0.812 1.176 (0.889–1.557) 0.254
pT Stage (3/4 vs.1/2) 1.679 (0.951–2.964) 0.074 1.670 (1.043–2.67) 0.033 1.459 (1.072–1.98) 0.016*
pN Stage (2/3 vs. 0/1) 3.332 (2.370–4.685) < 0.001 1.621 (1.243–2.11) < 0.001 1.708 (1.419–2.05) < 0.001*
Differentiation
  (Moderately vs. Well) 1.647 (1.067–2.541) 0.024 1.264 (0.915–1.747) 0.155 1.215 (0.973–1.518) 0.086
  (Poorly vs. Well) 2.395 (1.422–4.033) 0.001 1.201 (0.764–1.890) 0.427 1.224 (0.895–1.674) 0.205
Sex (Male vs. Female) 1.169 (0.596–2.292) 0.650 0.901 (0.541–1.49) 0.688 1.110 (0.752–1.63) 0.600
Age (> 60 vs. ≤60 years) 0.654 (0.654–1.237) 0.899 0.835 (0.639–1.090) 0.184 1.342 (1.114–1.616) 0.002*
Chemotherapy (Yes vs. no) 0.509 (0.361–0.717) < 0.001 0.742 (0.566–0.974) 0.032 0.718 (0.594–0.867) < 0.001*
TPT (days)
(> 85 vs. ≤85)
1.083 (0.788–1.490) 0.622 1.395 (1.038–1.734) 0.026 1.142 (0.948–1.313) 0.161
Alcohol (Yes vs. No) 1.291(0.921–1.811) 0.139 1.363 (1.026–1.81) 0.033 1.315 (1.078–1.60) 0.007*
Betel quid (Yes vs. no) 1.456 (0.961–2.208) 0.077 1.137 (0.823–1.570) 0.435 1.150 (0.919–1.432) 0.222
Smoking (Yes vs. no) 1.421 (0.846–2.385) 0.184 0.923 (0.637–1.336) 0.670 0.978 (0.752–1.2) 0.871
Comorbidity (Yes vs. no) 0.953 (0.839–1.585) 0.380 1.047 (0.803–1.366) 0.733 1.210 (1.006–1.456) 0.040*
S/RT interval 1.006 (0.708–1.428) 0.975 1.575 (1.142–2.172) 0.006 1.252(1.030–1.521) 0.024*
PET (Yes vs. no) 0.838 (0.610–1.153) 0.278 1.522 (1.161–1.997) 0.002 1.119 (0.928–1.350) 0.238
  1. Abbreviations: FFDM freedom from distant metastases, LRC locoregional control, OS overall survival, RT radiotherapy, TPT total package time, S surgery, PET positron emission tomography, HR hazard ratio, CI confidence interval. *Denotes statistically significant p values