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Table 2 Univariate analyses of freedom from distant metastases, locoregional control, and overall survival rates

From: Missed radiation therapy sessions in first three weeks predict distant metastasis and less favorable outcomes in surgically treated patients with oral cavity squamous cell carcinoma

 

FFDM

 

LRC

 

OS

 

Covariate

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

RT schedule

 Early missed RT vs. RT as scheduled

1.470 (0.946–2.283)

0.086

1.383 (0.920–2.079)

0.118

1.385 (1.052–1.821)

0.020*

 Late missed RT vs. RT as scheduled

0.916 (0.641–1.311)

0.632

1.453 (1.091–1.935)

0.011

1.177 (0.962–1.439)

0.112

 Early missed RT vs. late missed RT

1.602 (1.004–2.564)

0.048

1.050 (0.700–1.576)

0.812

1.176 (0.889–1.557)

0.254

pT Stage (3/4 vs.1/2)

1.679 (0.951–2.964)

0.074

1.670 (1.043–2.67)

0.033

1.459 (1.072–1.98)

0.016*

pN Stage (2/3 vs. 0/1)

3.332 (2.370–4.685)

< 0.001

1.621 (1.243–2.11)

< 0.001

1.708 (1.419–2.05)

< 0.001*

Differentiation

  (Moderately vs. Well)

1.647 (1.067–2.541)

0.024

1.264 (0.915–1.747)

0.155

1.215 (0.973–1.518)

0.086

  (Poorly vs. Well)

2.395 (1.422–4.033)

0.001

1.201 (0.764–1.890)

0.427

1.224 (0.895–1.674)

0.205

Sex (Male vs. Female)

1.169 (0.596–2.292)

0.650

0.901 (0.541–1.49)

0.688

1.110 (0.752–1.63)

0.600

Age (> 60 vs. ≤60 years)

0.654 (0.654–1.237)

0.899

0.835 (0.639–1.090)

0.184

1.342 (1.114–1.616)

0.002*

Chemotherapy (Yes vs. no)

0.509 (0.361–0.717)

< 0.001

0.742 (0.566–0.974)

0.032

0.718 (0.594–0.867)

< 0.001*

TPT (days)

(> 85 vs. ≤85)

1.083 (0.788–1.490)

0.622

1.395 (1.038–1.734)

0.026

1.142 (0.948–1.313)

0.161

Alcohol (Yes vs. No)

1.291(0.921–1.811)

0.139

1.363 (1.026–1.81)

0.033

1.315 (1.078–1.60)

0.007*

Betel quid (Yes vs. no)

1.456 (0.961–2.208)

0.077

1.137 (0.823–1.570)

0.435

1.150 (0.919–1.432)

0.222

Smoking (Yes vs. no)

1.421 (0.846–2.385)

0.184

0.923 (0.637–1.336)

0.670

0.978 (0.752–1.2)

0.871

Comorbidity (Yes vs. no)

0.953 (0.839–1.585)

0.380

1.047 (0.803–1.366)

0.733

1.210 (1.006–1.456)

0.040*

S/RT interval

1.006 (0.708–1.428)

0.975

1.575 (1.142–2.172)

0.006

1.252(1.030–1.521)

0.024*

PET (Yes vs. no)

0.838 (0.610–1.153)

0.278

1.522 (1.161–1.997)

0.002

1.119 (0.928–1.350)

0.238

  1. Abbreviations: FFDM freedom from distant metastases, LRC locoregional control, OS overall survival, RT radiotherapy, TPT total package time, S surgery, PET positron emission tomography, HR hazard ratio, CI confidence interval. *Denotes statistically significant p values