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Table 1 General characteristics of the study patients

From: Missed radiation therapy sessions in first three weeks predict distant metastasis and less favorable outcomes in surgically treated patients with oral cavity squamous cell carcinoma

 

RT as scheduled

Late missed RT

Early missed RT

Entire cohort

p value

Number

448

341

116

905

 

Sex, n (%)

    

0.210

 Women

26 (5.8%)

21 (6.2%)

12 (10.3%)

59 (6.5%)

 

 Men

422 (94.2%)

320 (93.8%)

104 (89.7%)

846 (93.5%)

 

Age (years), median (range)

50.8 (25.1–89.4)

51.1 (28.0–83.6)

49.8 (25.1–78.8)

50.8 (25.1–89.4)

0.330

Age (years), n (%)

    

0.481

  < 60

363 (81.0%)

274 (80.4%)

95 (81.9%)

732 (80.9%)

 

  ≥ 60

85 (19.0%)

67 (19.6%)

21 (18.1%)

173 (19.1%)

 

Differentiation

    

0.305

 Well differentiated

104 (23.2%)

87 (25.5%)

40 (34.5%)

232 (25.6%)

 

 Moderately differentiated

284 (63.4%)

199 (58.4%)

62 (53.5%)

545 (60.2%)

 

 Poorly differentiated

60 (13.4%)

55 (16.1%)

14 (12.0%)

128 (14.2%)

 

pStage, n (%)

    

0.710

 Stage I

6 (1.3%)

2 (0.6%)

0 (0%)

8 (0.9%)

 

 Stage II

16 (3.6%)

11 (3.2%)

2 (1.7%)

29 (3.2%)

 

 Stage III

123 (27.5%)

100 (29.3%)

33 (28.4%)

256 (28.3%)

 

 Stage IV

303 (67.6%)

228 (66.9%)

81 (69.8%)

612 (67.6%)

 

pT − Stage, n (%)

    

0.824

 T1/2

58 (12.9%)

40 (11.7%)

16 (13.8%)

114 (12.6%)

 

 T3/4

390 (87.1%)

301 (88.3%)

100 (86.2%)

791 (87.4%)

 

pN − Stage, n (%)

    

0.828

 N0/1

255 (56.9%)

198 (58.0%)

63 (54.3%)

516 (57.0%)

 

 N2/3

193 (43.1%)

143 (42.0%)

53 (45.7%)

389 (43.0%)

 

RTT (days), median (range)

46 (39–53)

49 (44–56)

50 (43–56)

47 (39–56)

0.131

 Mean ± SD

45.6 ± 2.52

49.0 ± 2.77

50.3 ± 2.94

47.5 ± 3.28

0.120

S/RT interval (days), median (range)

39 (15–106)

40 (15–94)

37 (17–77)

39 (15–106)

0.078

 Mean ± SD

40.2 ± 12.2

41.6 ± 13.4

38.4 ± 10.4

40.5 ± 12.5

0.061

S/RT interval (days), n (%)

    

0.256

  ≤ 42

326 (72.8%)

231 (67.7%)

85 (73.3%)

642 (70.9%)

 

  > 42

122 (27.2%)

110 (32.3%)

31 (26.7%)

263 (29.1%)

 

TPT (days), median (range)

84 (50–152)

88 (63–143)

86 (65–128)

86 (59–152)

0.058

 Mean ± SD

85.8 ± 12.4

90.5 ± 13.8

88.6 ± 10.7

88.0 ± 12.9

0.029

TPT (days), n (%)

    

< 0.001

  ≤ 85

254 (56.7%)

133 (39.0%)

49 (42.2%)

436 (48.2%)

 

  > 85

194 (43.3%)

208 (61.0%)

67 (57.7%)

469 (51.8%)

 

RT techniques

    

0.691

 2D RT

76 (16.9%)

68 (19.9%)

20 (17.2%)

164 (18.1%)

 

 3D conformal RT

43 (9.6%)

14 (4.1%)

12 (10.3%)

69 (7.6%)

 

 IMRT

296 (66.1%)

223 (65.4%)

80 (70.0%)

599 (66.2%)

 

 VMAT

33 (7.4%)

36 (10.6%)

4 (3.5%)

73 (8.1%)

 

Chemotherapy, n (%)

    

0.933

 Yes

248 (55.4%)

190 (55.7%)

67 (57.8%)

505 (55.8%)

 

 No

200 (44.6%)

151 (44.3%)

49 (42.2%)

400 (44.2%)

 

PET imaging, n (%)

    

0.095

 Yes

233 (52.0%)

151 (44.3%)

58 (50.0%)

442 (48.8%)

 

 No

215 (48.0%)

190 (55.7%)

58 (50.0%)

463 (51.2%)

 

Smoking, n (%)

    

0.864

 No

65 (14.5%)

46 (13.5%)

18 (15.5%)

129 (14.3%)

 

 Yes

383 (85.5%)

295 (86.5%)

98 (84.5%)

776 (85.7%)

 

Betel quid chewing, n (%)

    

0.366

 No

94 (21.0%)

85 (24.9%)

29 (25.0%)

208 (23.0%)

 

 Yes

354 (79.0%)

256 (75.1%)

87 (75.0%)

697 (77.0%)

 

Alcohol use, n (%)

    

0.171

 No

182 (40.6%)

116 (34.0%)

43 (37.1%)

341 (37.7%)

 

 Yes

266 (59.4%)

225 (66.0%)

73 (62.9%)

564 (62.3%)

 

Comorbidities, n (%)

    

0.227

 No

237 (52.9%)

159 (46.6%)

61 (52.6%)

456 (50.3%)

 

 Yes

211 (47.1%)

182 (53.4%)

55 (47.4%)

448 (49.5%)

 
  1. Data are given as counts (percentages), means ± standard deviations, or medians (ranges), as appropriate. Abbreviations: RT radiotherapy, RTT radiation treatment time, S surgery, SD standard deviation, TPT treatment package time, 2D two-dimensional, 3D three-dimensional, IMRT intensity-modulated radiation therapy, VMAT volumetric-modulated arc therapy, PET positron emission tomography