Factors distinguishing invasive from pre-invasive adenocarcinoma presenting as pure ground glass pulmonary nodules

Table 2 Optimal cutoff values for continuous predictors

Indicator	AUC	p	Cut off value^a	Sensitivity	Specificity	PPV	NPV
Age (years)	0.704 (0.657,0.751)	< 0.001	53	52%	79%	91%	30%
Serum CEA (μg/L)	0.495 (0.440,0.550)	0.862	2.19	90%	15%	80%	28%
Max diameter (mm)	0.845 (0.805,0.885)	< 0.001	10.78	81%	79%	94%	52%
CT value (HU)	0.664 (0.613,0.715)	< 0.001	−582.28	66%	60%	87%	32%
Mean diameter (mm)	0.852 (0.813,0.89)	< 0.001	10.09	86%	75%	93%	58%

^aCutoff values were determined via the maximal Youden index (sensitivity + specificity −1).AUC area under the receiver operating characteristic curve, CEA carcinoembryonic antigen, CT computed tomography, HU Hounsfield units, Max maximal, NPV negative predictive value, PPV positive predictive value

ISSN: 1748-717X