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Table 5 The comparison between automated and manual IMRT plans for 25 patients with locally advanced nasopharyngeal carcinoma

From: A knowledge-based intensity-modulated radiation therapy treatment planning technique for locally advanced nasopharyngeal carcinoma radiotherapy

ROI

Parameter

Criteria

Number

Parameter

AP

MP

AP (mean ± SD)

MP (mean ± SD)

P

GTV_T_P

D5(Gy)

   

76.27 ± 0.59

76.43 ± 0.98

0.756

D95(Gy)

68.96Gy ~ 70.96Gy

20

22

69.61 ± 0.64

70.21 ± 0.59

0.001*

CI

   

0.793 ± 0.039

0.792 ± 0.044

0.839

HI

   

1.096 ± 0.017

1.089 ± 0.022

0.09

CTV1_P

D95(Gy)

> 61.05Gy

24

25

63.53 ± 0.66

64.41 ± 0.81

< 0.001*

CI

   

0.759 ± 0.044

0.728 ± 0.048

0.024

CTV2_P

D95(Gy)

> 56.1Gy

24

25

57.11 ± 0.58

57.93 ± 0.66

< 0.001*

CI

   

0.856 ± 0.022

0.849 ± 0.021

0.265

GTV_NL_P

D5(Gy)

   

69.17 ± 0.82

68.86 ± 1.10

0.087

D95(Gy)

65.5Gy ~ 67Gy

23

24

66.29 ± 0.40

66.18 ± 0.32

0.169

CI

   

0.487 ± 0.100

0.471 ± 0.117

0.961

HI

   

1.044 ± 0.017

1.040 ± 0.016

0.587

GTV_NR_P

D5(Gy)

   

69.17 ± 0.59

68.63 ± 0.64

0.003

D95(Gy)

65.5Gy ~ 67Gy

24

25

66.47 ± 0.37

66.25 ± 0.28

0.006

CI

   

0.474 ± 0.082

0.484 ± 0.082

0.635

HI

   

1.041 ± 0.011

1.036 ± 0.009

0.146

CTV_NL_P

D95(Gy)

> 52.8Gy

25

25

54.06 ± 0.51

54.97 ± 0.58

< 0.001*

CI

   

0.666 ± 0.036

0.666 ± 0.040

0.884

CTV_NR_P

D95(Gy)

> 52.8Gy

25

25

54.18 ± 0.47

54.83 ± 0.59

0.001*

CI

   

0.653 ± 0.034

0.653 ± 0.037

0.778

Left parotid

V30(%)

< 50%

20

21

45.36 ± 5.06

47.14 ± 4.97

0.091

Right parotid

V30(%)

< 50%

20

20

45.75 ± 5.16

47.43 ± 5.13

0.177

Brainstem

D1cc(Gy)

<65Gy

24

23

56.19 ± 6.87

54.95 ± 7.8

0.449

Spinal cord

D1Gy)

<45Gy

23

23

40.23 ± 3.06

40.56 ± 3.59

0.691

Left optic lens

Dmax(Gy)

<8Gy

25

25

5.03 ± 0.87

5.06 ± 0.93

0.861

Right optic lens

Dmax(Gy)

<8Gy

25

25

4.79 ± 0.54

5.02 ± 0.70

0.206

Left optic nerve

Dmax(Gy)

<62Gy

23

23

32.85 ± 19.08

40 ± 20.35

0.677

Right optic nerve

Dmax(Gy)

<62Gy

20

19

33.99 ± 21.58

37.58 ± 21.39

0.473

Pituitary

Dmax(Gy)

<66Gy

17

15

53.55 ± 18.20

55.12 ± 19.17

0.547

Optic chiasm

Dmax(Gy)

<66Gy

21

19

43.52 ± 23.24

44.69 ± 23.8

0.892

MU

   

685.04 ± 59.63

721.36 ± 63.36

0.051

Duration (min)

   

9.85 ± 1.13

57.10 ± 6.35

< 0.001*

  1. ROI Region of interest, AP Automated plan, MP Manual plan
  2. *P < 0.0015 indicates statistical significance
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Radiation Oncology

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