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Table 2 Proposed radiation tolerance of organs at risk for reirradiation

From: Carbon ion reirradiation compared to intensity-modulated re-radiotherapy for recurrent head and neck cancer (CARE): a randomized controlled trial

  Maximum cumulative BED2Gy (RT interval < 2 years) Maximum cumulative BED2Gy (RT interval ≥ 2 years) Comment
Brain stem (α/β = 2) 60 78 ( + 30%) Maximum (surface)
Optic chiasm (α/β = 3) 54 64.8 ( + 20%) Maximum
Optic nerves (α/β = 3) 54 64.8 ( + 20%) Maximum
Spinal cord (α/β = 2) 45 54 ( + 20%) Maximum
Other organs at risk ALARA* /
  1. Abbreviations: BED2Gy biological effective dose in 2 Gy fractions, RT radiotherapy, ALARA as low as reasonably achievable