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Table 2 Proposed radiation tolerance of organs at risk for reirradiation

From: Carbon ion reirradiation compared to intensity-modulated re-radiotherapy for recurrent head and neck cancer (CARE): a randomized controlled trial

 

Maximum cumulative BED2Gy (RT interval < 2 years)

Maximum cumulative BED2Gy (RT interval ≥ 2 years)

Comment

Brain stem (α/β = 2)

60

78 ( + 30%)

Maximum (surface)

Optic chiasm (α/β = 3)

54

64.8 ( + 20%)

Maximum

Optic nerves (α/β = 3)

54

64.8 ( + 20%)

Maximum

Spinal cord (α/β = 2)

45

54 ( + 20%)

Maximum

Other organs at risk

ALARA*

/

  1. Abbreviations: BED2Gy biological effective dose in 2 Gy fractions, RT radiotherapy, ALARA as low as reasonably achievable