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Table 1 Dose specification for reIMRT and reCIRT

From: Carbon ion reirradiation compared to intensity-modulated re-radiotherapy for recurrent head and neck cancer (CARE): a randomized controlled trial

 

CTV reIMRT

CTV reCIRT

Dose per fraction

2 Gy

3 Gy (RBE)

Total dose

54–60 Gy

51–60 Gy (RBE)

BED2Gya

/

64–75 Gy

  1. Abbreviations: reIMRT intensity-modulated re-radiotherapy, reCIRT carbon ion reirradiation, CTV clinical target volume, RBE relative biological effectiveness, BED2Gy biological effective dose in 2 Gy fractions, acalculated according to the local effect model (LEM I) with an assumed alpha/beta of 2