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Table 2 PDAC related diagnostic aptamers

From: Aptamers: a novel targeted theranostic platform for pancreatic ductal adenocarcinoma

Name

Target

SELEX method

Positive selection

Negative selection

Oligos

Applications

Model

Ref.

M9–5

Cyclophilin B

Secretome

MiaPaCa-2

HPDE

RNA

biomarker detection

Patients and

[45]

KPC mice serum

[44]

C14B

AGR2

Protein

AGR2-GST

GST

DNA

probe generation

In vitro

[68]

SQ-2

ALPPL-2

Cell

Panc-1

HPDE

RNA

biomarker detection

In vitro

[38]

Capan-1

biosensor generation

[39]

BC-15

hnRNP A1

Tissue

PDAC

Adjacent normal tissue

DNA

CTCs detection

Patients serum

[46]

XQ-2d

CD71

Cell

PL45

hTERT-HPNE

DNA

biomarker detection

In vitro

[40]

Cy-5-labeled fluorescence imaging

Xenograft model Human sections

[93]

PL8

HPAC

Cell

PL45

TOV-21G

DNA

New biomarker detection

In vitro

[41]

Apt.1

CSCs

Cell

HPAC (CRL2119)

HPDE

DNA

CSCs detection;

In vitro

[42]

Apt.146

CSCs

Cell

HPAC (CRL2119)

HPDE

DNA

New biomarker detection

In vitro

[42]

Ap52

MAGE-A3

Peptide

MAGE-A3111–125

None

DNA

Cy-3-labeled fluorescence imaging

In vitro

[49]

P19/P1

HPAC

Cell

PANC-1

Huh7

RNA

Cy-3-labeled fluorescence imaging

Human tumor tissue sections

[55]

AP1153

CCKBR

Peptides

CCKBR peptides

COS-1

DNA

ICG labeled fluorescence imaging

Orthotopic model

[94]

Cell

PANC-1

M17

MMP14

Cell

293 T-MMP14 cells

293 T cells

DNA

Cy-3-labeled fluorescence imaging

Xenograft model

[51]