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Table 1 PDAC related aptasensors for biomarkers detection

From: Aptamers: a novel targeted theranostic platform for pancreatic ductal adenocarcinoma

Aptamers against biomarker Nanocarriers Detection method Oligos Linear dynamic range (LDR) Limit of detection
(LOD)
Detection model Ref.
CA 19–9 None Fluorescence DNA Kd value
20.05 ± 3.02 nmol/L
Not tested in serum [18]
CEA Zirconium metal-organic framework of silver nanoclusters (AgNCs) ECL and SPR DNA 1.0–250 ng/mL 0.3 ng/ml Human serum [90]
CEA Ru@SiO2 − AuNPs ECL DNA 5.0–50,000 fg/mL 1.52 fg/ml Human serum [91]
CEA CdS-GR-AuNPs ECL DNA 0.01–10.0 ng/ml 3.8 pg/ml Human serum [92]
IL-6 Carbon nanotube ECL RNA 1 pg/mL to 10 ng/mL 1 pg/ml Human serum [33]
MMP-9 None SPR DNA 0.56 ng/ml Commercial serum [29]
VEGF Quantum dots Fluorescence DNA 50 pmol/L Human serum [34]
VEGF None ECL DNA 50 pmol/L to 0.15 nmol/L 5 pmol/L (190 pg/mL) 50% serum [35]
VEGF Carbon–gold nanocomposite ECL DNA 10 to 300 pg/ml 1 pg/ml Human serum [48]