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Table 1 Outcome of retrospective studies on radiotherapy for lentigo maligna and lentigo maligna melanoma

From: Radiotherapy for lentigo maligna and lentigo maligna melanoma – a systematic review

First author

Year

Center

Period

Sample size

Local recurrence rate

Complete response rate

Follow-up duration

Cosmetic results

Notes

Lazarevic [10]

2019

Zurich, Switzerland

2009–2014

27 LM, 18 M

15% (LM), 17% (M)

n.a.

51 months (mean)

«good»

periocular lesions, 44% of melanoma patients with immunosuppression, 11% LM

Lamoureux [11]

2018

Bordeaux, France

2007–2017

42 LM, 6 LMM, 13 LMM with previous surgery

10% (overall), 7% (only LM)

n.a.

22 months (mean), range 3–70 months

9.8% hypopigmentation, 8.1% teleangiectasia, no fibrosis

Conference abstract only

Hedblad [12]

2012

Stockholm, Sweden

1990–2009

593 LM or early LMM; 59% primary RT; 12% after partial excision, 29% adjuvant RT after complete excision

Overall 12% (17% primary RT, 9% RT after partial excision, 3% RT after complete excision)

88% (primary RT); 90% (RT after partial excision); 97% (RT after complete excision)

425 patients for at least 24 months, 241 for more than 60 months

«excellent» (15% hypopigmentation, 20% hyperpigmentation, «some» teleangiectasia)

86% facial localization

Lee [13]

2011

London, Ontario, Canada

1991–2005

31 LM

29% (LM)

n.a.

46.3 months (median)

19.4% teleangiectasia, 6.5% hypopigmentation

89.3% head and neck region

Zalaudek [14]

2003

Graz, Austria

1990–2000

15 LM

13% (LM)

n.a.

5-year recurrence rate reported

n.a.

All lesions in head and neck region

Farshad [15]

2002

Zurich, Switzerland

1950–2000

93 LM, 54 LMM, 3 LM and LMM (more than one lesion in 4%)

7% overall, (for 101 patients with a follow-up of at least 2 years)

n.a.

8 years (mean)

«acceptable»

90% facial localization

Schmid-Wendtner [16]

2000

Munich, Germany

1987–1998

42 LM, 22 LMM

0% (LM), 9% (LMM)

n.a.

15 months (median, range 1–96)

“good or excellent”, no ulcers or fibrosis

98% head and neck region

Christie [17]

1996

Westmead, Australia

1989–1995

5 LM

0% (LM)

100% (LM)

16 months (median, range 8–37 months

«favourable», teleangiectasia in 2 patients

All lesions in head and neck region

Tsang [18]

1994

Toronto, Ontario, Canada

1968–1988

36 LM

11% (LM)

n.a.

72 months (median)

«acceptable», «poor» in 11% (skin pallor, atrophy, teleangiectasia)

18 patients already included in previous publication [19]; 92% head and neck area

Harwood [19]

1983

Toronto, Ontario, Canada

1958–1982

23 LM, 28 LMM

10% (LM), 8% (LMM)

n.a.

LM: (26 months (median, range 5–96 months); LMM: 24 months (median, range 6–96 months)

n.a.

96% head and neck region

Richter [20]

1977

Dresden, Germany

1957–1975

12 LM, 5 LMM

0%

100%

12–84 months

“excellent”

79% head and neck region; publication in German

Kopf [21]

1976

New York, USA

1964–1973

16 LM

31%

94%

median: 32.5 months (range 6–113)

“fair to excellent” in most cases

 

Braun-Falco [22]

1975

Munich, Germany

1955–1970

68 LM

0% (LM)

100% (LM)

36 months (mean, range 12–120 months)

«good»

86% facial or head area; histological diagnosis only in 10 cases; publication in German

Arma-Szlachcic [23]

1970

Zurich, Switzerland

1941–1965

69 LM, 19 LMM

3% (LM), 0% (LMM, but metastatic spread in 26%)

100% (LM)

at least 60 months in 74 patients

n.a.

84% facial localization; publication in German

  1. LM Lentigo maligna; LMM Lentigo maligna melanoma; M Melanoma (not further specified); n.a. Not available; RT Radiotherapy