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Table 1 Characteristics of the included studies

From: Oncologic outcomes of pre- versus post-operative radiation in Resectable soft tissue sarcoma: a systematic review and meta-analysis

Study included

Study design

Sample size

Means of follow-up time (years)

Localization

Outcomes

PRCT

POCT

PRCT

POCT

Frezza, et al., 1982 [22]

Retrospective

50

49

4.75

Extremities, Trunk, Head/Neck

LC: 2/50

WC:4/50

LC: 5/49

WC:2/49

Suit, et al., 1985 [23]

Retrospective

60

110

1.00–11.00 a

Extremities, Trunk, Head/Neck

LCO: 0.86 (0.73–0.94) f

LC: 6/60

OS:37/60

LCO:0.84 (0.74–0.90) f

LC: 13/110

OS:80/110

Cheng, et al.,1996 [24]

Retrospective

48

64

5.30 (1.25–16.00) b

Extremities, Trunk, Head/Neck

LCO: 0.80 ± 0.12 g

LC: 7/48

OS:34/48

WC:15/48

LCO: 0.91 ± 0.08 g

LC:6/64

OS:35/64

WC:5/64

Pollack, et al.,1998 [25]

Retrospective

128

165

8.75

Extremities, Trunk, Head/Neck

LCO: 0.88

OS: 32/128

LCO: 0.73

OS: 10/165

O’Sullivan,et.al.,2002 [11]

RCT

88

94

3.30 (0.27–5.60) b

Extremities, Trunk, Head/Neck

WC: 31/88

OS: 74/88

LR: 6/88

DM: 0/88

WC: 16/94

OS: 68/94

LR: 6/94

DM:1/94

Zagars, et al.,2003 [12]

Retrospective

271

246

6.40 (1.70–29.9)/ 9.10 (1.30–29.20) c

Extremities, Trunk, Head/Neck

LR:36/271

OS: 108/271

DM: 98/271

LR: 56/246

OS: 144/246

DM: 87/234

Kuklo, et al.,2005 [13]

Retrospective

59

58

6.10/8.40 d

Extremities, Trunk, Head/Neck

OS: 49/59

WC: 19/59

OS: 48/58

WC: 17/58

Schoenfeld, et al.,2006 [26]

Retrospective

7

16

11.00 (1.20–25.8) b

Extremities, Trunk, Head/Neck

LR: 1/7

LR: 1/16

Jebsen, et al.,2008 [27]

Retrospective

106

356

5.00 (0.10–20.00) b

Extremities, Trunk, Head/Neck

LR: 12/107

OS: 53/107

LR: 45/356

OS: 163/356

Sampath, et al.,2011 [28]

Retrospective

293

528

5.25 (0.00–17.00) b

Both

LCO: 0.93

OS: 190/293

LCO: 0.87

OS: 317/528

El-Sayed, et al.,2012 [29]

Prospective

24

39

3.92 (0.50–5.50) b

Extremities, Trunk, Head/Neck

LCO: 0.87

LR: 2/24

OS: 21/24

WC: 6/24

LCO: 0.76

LR: 6/39

OS: 31/39

WC: 3/39

Moore, et al.,2014 [30]

Retrospective

122

62

10.00

NA

WC: 29/122

WC: 5/62

Toulmonde, et al.,2014 [31]

Retrospective

13

62

6.50

Retroperitoneum

LR: 0/13

OS: 1/13

LR: 33/62

OS: 45/92

Lazarev, et al.,2017 [14]

Retrospective

2358

7246

6.90

Extremities, Trunk, Head/Neck

OS: 1542/2358

OS: 5166/7246

Greto, et al.,2019 [32]

Retrospective

19

72

4.10 (0.10–17.70) b

Extremities, Trunk, Head/Neck

LR: 5/15

OS: 15/19

DM: 10/19

LR: 14/72

OS: 38/72

DM: 33/75

  1. Abbreviations: PRCT preoperative radiotherapy, POCT postoperative radiotherapy, OS overall survival, disease-free, DFS, LC local recurrence, Local control LCO, WC wound complication, DM distant metastasis, NA not available
  2. a, range of follow time
  3. b, means and range of follow time
  4. c, means and range of follow time for preoperative and postoperative, respectively
  5. d, means of follow time for preoperative and postoperative, respectively
  6. f, 95% confidence interval
  7. g, strand deviation