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Table 2 Induction of micronuclei by ionizing radiation of 18F-FDG in human lymphocytes in vitro

From: Radioprotective efficacy of plastic polymer against the toxicogenomic effects of radiopharmaceutical 18F-FDG on human lymphocytes

Shielding

Distribution of BNC according to the number of MN

MN/BNC ± SD (%)

CMN/BNC ± SD (%)

NPB/CBN ± SD (‰)

NBUD/CBN ± SD (‰)

CBPI ± SD

1

2

3

4

Negative Control

14

1

0

0

1.55 ± 0.19

1.48 ± 0.18

1.00 ± 0.63

0.83 ± 0.75

2.09 ± 0.05

18F-FDG Unshielded

53

3

2

2

7.13 ± 0.70a

5.92 ± 0.68a

5.83 ± 0.75a

4.67 ± 1.75a

1.60 ± 0.06a

18F-FDG + Lead

39

2

1

1

4.78 ± 0.33ab

4.22 ± 0.19ab

1.17 ± 0.75b

0.50 ± 0.55b

1.99 ± 0.03ab

18F-FDG + Polymer

46

3

1

1

6.02 ± 0.20ab

5.10 ± 0.14ab

2.50 ± 1.05ab

1.83 ± 0.75ab

1.88 ± 0.04ab

18F-FDG + Lead + Polymer

38

1

1

0

4.30 ± 0.23ab

3.98 ± 0.23ab

1.50 ± 0.55b

0.83 ± 0.75b

2.06 ± 0.04b

  1. Number of binucleated cells analyzed for each individual in each repetition = 1000
  2. BNC binucleated cells, MN micronucleus, CMN cell with one or more micronuclei, NPB nucleoplasmic bridge, NBUD nuclear bud, CBPI Cytokinesis-Block Proliferation Index
  3. a Statistically significant difference from the negative control (p < 0.05)
  4. b Statistically significant difference from the unshielded group (p < 0.05)