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Table 2 Induction of micronuclei by ionizing radiation of 18F-FDG in human lymphocytes in vitro

From: Radioprotective efficacy of plastic polymer against the toxicogenomic effects of radiopharmaceutical 18F-FDG on human lymphocytes

Shielding Distribution of BNC according to the number of MN MN/BNC ± SD (%) CMN/BNC ± SD (%) NPB/CBN ± SD (‰) NBUD/CBN ± SD (‰) CBPI ± SD
1 2 3 4
Negative Control 14 1 0 0 1.55 ± 0.19 1.48 ± 0.18 1.00 ± 0.63 0.83 ± 0.75 2.09 ± 0.05
18F-FDG Unshielded 53 3 2 2 7.13 ± 0.70a 5.92 ± 0.68a 5.83 ± 0.75a 4.67 ± 1.75a 1.60 ± 0.06a
18F-FDG + Lead 39 2 1 1 4.78 ± 0.33ab 4.22 ± 0.19ab 1.17 ± 0.75b 0.50 ± 0.55b 1.99 ± 0.03ab
18F-FDG + Polymer 46 3 1 1 6.02 ± 0.20ab 5.10 ± 0.14ab 2.50 ± 1.05ab 1.83 ± 0.75ab 1.88 ± 0.04ab
18F-FDG + Lead + Polymer 38 1 1 0 4.30 ± 0.23ab 3.98 ± 0.23ab 1.50 ± 0.55b 0.83 ± 0.75b 2.06 ± 0.04b
  1. Number of binucleated cells analyzed for each individual in each repetition = 1000
  2. BNC binucleated cells, MN micronucleus, CMN cell with one or more micronuclei, NPB nucleoplasmic bridge, NBUD nuclear bud, CBPI Cytokinesis-Block Proliferation Index
  3. a Statistically significant difference from the negative control (p < 0.05)
  4. b Statistically significant difference from the unshielded group (p < 0.05)