Table 1 Dose levels used for dose escalation. Two separate viral particle doses are used with escalation achieved by increasing the frequency of administration. Administrations of the virus are highlighted by the green arrows in Fig. 1
Dose schedule | Loading (Pre CRT) (3 doses given on 3 non-consecutive days over a 7 day period) | Concurrent | Maintenance (post CRT)(3 doses given on 3 non-consecutive days over a 7 day period) | |
|---|---|---|---|---|
Week 1 Day 1 CRT (week 3 day 1) | Week 1 Day 5 CRT (week 3 day 5) | |||
1 (start level) | 1 × 1012vp | |||
2 | 1 × 1012vp | 1 × 1012vp | ||
3 | 1 × 1012vp | 1 × 1012vp | 1 × 1012vp | 1 × 1012vp |
4 | 3 × 1012vp | |||
5 | 3 × 1012vp | 3 × 1012vp | ||
6 | 3 × 1012vp | 3 × 1012vp | 3 × 1012vp | 3 × 1012vp |