TY - JOUR AU - Bray, F. AU - Ferlay, J. AU - Soerjomataram, I. AU - Siegel, R. L. AU - Torre, L. A. AU - Jemal, A. PY - 2018 DA - 2018// TI - Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries JO - CA Cancer J Clin VL - 68 UR - https://doi.org/10.3322/caac.21492 DO - 10.3322/caac.21492 ID - Bray2018 ER - TY - STD TI - Li D, Xie K, Wolff R, Abbruzzese JL. Pancreatic cancer. Lancet. 2004;363(9414):1049–57. https://doi.org/10.1016/S0140-6736(04)15841-8. ID - ref2 ER - TY - JOUR AU - Cardenes, H. R. AU - Moore, A. M. AU - Johnson, C. S. PY - 2011 DA - 2011// TI - A phase II study of gemcitabine in combination with radiation therapy in patients with localized, unresectable, pancreatic cancer: a Hoosier oncology group study JO - Am J Clin Oncol VL - 34 UR - https://doi.org/10.1097/COC.0b013e3181e9c103 DO - 10.1097/COC.0b013e3181e9c103 ID - Cardenes2011 ER - TY - JOUR AU - Bittner, M. -. I. AU - Grosu, A. -. L. AU - Brunner, T. B. PY - 2015 DA - 2015// TI - Comparison of toxicity after IMRT and 3D-conformal radiotherapy for patients with pancreatic cancer - a systematic review JO - Radiother Oncol VL - 114 UR - https://doi.org/10.1016/j.radonc.2014.11.043 DO - 10.1016/j.radonc.2014.11.043 ID - Bittner2015 ER - TY - JOUR AU - Polistina, F. AU - Costantin, G. AU - Casamassima, F. PY - 2010 DA - 2010// TI - Unresectable locally advanced pancreatic cancer: a multimodal treatment using neoadjuvant chemoradiotherapy (gemcitabine plus stereotactic radiosurgery) and subsequent surgical exploration JO - Ann Surg Oncol VL - 17 UR - https://doi.org/10.1245/s10434-010-1019-y DO - 10.1245/s10434-010-1019-y ID - Polistina2010 ER - TY - JOUR AU - Ben-Josef, E. AU - Schipper, M. AU - Francis, I. R. PY - 2012 DA - 2012// TI - A phase I/II trial of intensity modulated radiation (IMRT) dose escalation with concurrent fixed-dose rate gemcitabine (FDR-G) in patients with unresectable pancreatic cancer JO - Int J Radiat Oncol Biol Phys VL - 84 UR - https://doi.org/10.1016/j.ijrobp.2012.02.051 DO - 10.1016/j.ijrobp.2012.02.051 ID - Ben-Josef2012 ER - TY - JOUR AU - Takatori, K. AU - Terashima, K. AU - Yoshida, R. PY - 2014 DA - 2014// TI - Upper gastrointestinal complications associated with gemcitabine-concurrent proton radiotherapy for inoperable pancreatic cancer JO - J Gastroenterol VL - 49 UR - https://doi.org/10.1007/s00535-013-0857-3 DO - 10.1007/s00535-013-0857-3 ID - Takatori2014 ER - TY - JOUR AU - Terashima, K. AU - Demizu, Y. AU - Hashimoto, N. PY - 2012 DA - 2012// TI - A phase I/II study of gemcitabine-concurrent proton radiotherapy for locally advanced pancreatic cancer without distant metastasis JO - Radiother Oncol VL - 103 UR - https://doi.org/10.1016/j.radonc.2011.12.029 DO - 10.1016/j.radonc.2011.12.029 ID - Terashima2012 ER - TY - JOUR AU - Kelly, P. AU - Das, P. AU - Pinnix, C. C. PY - 2013 DA - 2013// TI - Duodenal toxicity after fractionated Chemoradiation for Unresectable pancreatic Cancer JO - Int J Radiat Oncol. VL - 85 UR - https://doi.org/10.1016/J.IJROBP.2012.09.035 DO - 10.1016/J.IJROBP.2012.09.035 ID - Kelly2013 ER - TY - JOUR AU - Nichols, R. C. AU - George, T. J. AU - Zaiden, R. A. PY - 2013 DA - 2013// TI - Proton therapy with concomitant capecitabine for pancreatic and ampullary cancers is associated with a low incidence of gastrointestinal toxicity JO - Acta Oncol (Madr). VL - 52 UR - https://doi.org/10.3109/0284186X.2012.762997 DO - 10.3109/0284186X.2012.762997 ID - Nichols2013 ER - TY - JOUR AU - Sachsman, S. AU - Nichols, R. C. AU - Morris, C. G. PY - 2014 DA - 2014// TI - Proton Therapy and Concomitant Capecitabine for Non-Metastatic Unresectable Pancreatic Adenocarcinoma JO - Int J Part Ther VL - 1 UR - https://doi.org/10.14338/ijpt.14-00006.1 DO - 10.14338/ijpt.14-00006.1 ID - Sachsman2014 ER - TY - JOUR AU - Langen, K. AU - Zhu, M. PY - 2018 DA - 2018// TI - Concepts of PTV and robustness in passively scattered and pencil beam scanning proton therapy JO - Semin Radiat Oncol VL - 28 UR - https://doi.org/10.1016/j.semradonc.2018.02.009 DO - 10.1016/j.semradonc.2018.02.009 ID - Langen2018 ER - TY - JOUR AU - Stuschke, M. AU - Kaiser, A. AU - Jawad, J. A. AU - Pöttgen, C. AU - Levegrün, S. AU - Farr, J. PY - 2013 DA - 2013// TI - Multi-scenario based robust intensity-modulated proton therapy (IMPT) plans can account for set-up errors more effectively in terms of normal tissue sparing than planning target volume (PTV) based intensity-modulated photon plans in the head and neck regi JO - Radiat Oncol VL - 8 UR - https://doi.org/10.1186/1748-717X-8-145 DO - 10.1186/1748-717X-8-145 ID - Stuschke2013 ER - TY - JOUR AU - Stefanowicz, S. AU - Stützer, K. AU - Zschaeck, S. AU - Jakobi, A. AU - Troost, E. G. C. PY - 2018 DA - 2018// TI - Comparison of different treatment planning approaches for intensity-modulated proton therapy with simultaneous integrated boost for pancreatic cancer JO - Radiat Oncol VL - 13 UR - https://doi.org/10.1186/s13014-018-1165-0 DO - 10.1186/s13014-018-1165-0 ID - Stefanowicz2018 ER - TY - JOUR AU - Bouchard, M. AU - Amos, R. A. AU - Briere, T. M. AU - Beddar, S. AU - Crane, C. H. PY - 2009 DA - 2009// TI - Dose escalation with proton or photon radiation treatment for pancreatic cancer JO - Radiother Oncol VL - 92 UR - https://doi.org/10.1016/j.radonc.2009.04.015 DO - 10.1016/j.radonc.2009.04.015 ID - Bouchard2009 ER - TY - JOUR AU - Thompson, R. F. AU - Mayekar, S. U. AU - Zhai, H. PY - 2014 DA - 2014// TI - A dosimetric comparison of proton and photon therapy in unresectable cancers of the head of pancreas JO - Med Phys VL - 41 UR - https://doi.org/10.1118/1.4887797 DO - 10.1118/1.4887797 ID - Thompson2014 ER - TY - JOUR AU - Langendijk, J. A. AU - Lambin, P. AU - Ruysscher, D. AU - Widder, J. AU - Bos, M. AU - Verheij, M. PY - 2013 DA - 2013// TI - Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach JO - Radiother Oncol VL - 107 UR - https://doi.org/10.1016/j.radonc.2013.05.007 DO - 10.1016/j.radonc.2013.05.007 ID - Langendijk2013 ER - TY - JOUR AU - Murphy, J. D. AU - Adusumilli, S. AU - Griffith, K. A. PY - 2007 DA - 2007// TI - Full-dose gemcitabine and concurrent radiotherapy for Unresectable pancreatic Cancer JO - Int J Radiat Oncol Biol Phys VL - 68 UR - https://doi.org/10.1016/j.ijrobp.2006.12.053 DO - 10.1016/j.ijrobp.2006.12.053 ID - Murphy2007 ER - TY - JOUR AU - McGinn, C. J. AU - Zalupski, M. M. AU - Shureiqi, I. PY - 2001 DA - 2001// TI - Phase I trial of radiation dose escalation with concurrent weekly full-dose gemcitabine in patients with advanced pancreatic cancer JO - J Clin Oncol VL - 19 UR - https://doi.org/10.1200/JCO.2001.19.22.4202 DO - 10.1200/JCO.2001.19.22.4202 ID - McGinn2001 ER - TY - JOUR AU - Wong, J. W. AU - Sharpe, M. B. AU - Jaffray, D. A. PY - 1999 DA - 1999// TI - The use of active breathing control (ABC) to reduce margin for breathing motion JO - Int J Radiat Oncol Biol Phys VL - 44 UR - https://doi.org/10.1016/S0360-3016(99)00056-5 DO - 10.1016/S0360-3016(99)00056-5 ID - Wong1999 ER - TY - JOUR AU - Nakamura, A. AU - Shibuya, K. AU - Matsuo, Y. PY - 2012 DA - 2012// TI - Analysis of dosimetric parameters associated with acute gastrointestinal toxicity and upper gastrointestinal bleeding in locally advanced pancreatic cancer patients treated with gemcitabine-based concurrent chemoradiotherapy JO - Int J Radiat Oncol Biol Phys VL - 84 UR - https://doi.org/10.1016/j.ijrobp.2011.12.026 DO - 10.1016/j.ijrobp.2011.12.026 ID - Nakamura2012 ER - TY - STD TI - Uzawa A, Ando K, Furusawa Y, et al. Biological Intercomparison Using Gut Crypt Survivals for Proton and Carbon-Ion Beams. 2007;48 http://jrr.jstage.jst.go.jp. Accessed June 12, 2019. UR - http://jrr.jstage.jst.go.jp ID - ref22 ER - TY - JOUR AU - Chuong, M. AU - Badiyan, S. N. AU - Yam, M. PY - 2018 DA - 2018// TI - Pencil beam scanning versus passively scattered proton therapy for unresectable pancreatic cancer JO - J Gastrointest Oncol VL - 9 UR - https://doi.org/10.21037/jgo.2018.03.14 DO - 10.21037/jgo.2018.03.14 ID - Chuong2018 ER - TY - JOUR AU - Huang, J. AU - Robertson, J. M. AU - Ye, H. AU - Margolis, J. AU - Nadeau, L. AU - Yan, D. PY - 2012 DA - 2012// TI - Dose–volume analysis of predictors for gastrointestinal toxicity after concurrent full-dose gemcitabine and radiotherapy for locally advanced pancreatic adenocarcinoma JO - Int J Radiat Oncol. VL - 83 UR - https://doi.org/10.1016/J.IJROBP.2011.09.022 DO - 10.1016/J.IJROBP.2011.09.022 ID - Huang2012 ER - TY - JOUR AU - Nichols, R. C. AU - Huh, S. N. AU - Prado, K. L. PY - 2012 DA - 2012// TI - Protons offer reduced Normal-tissue exposure for patients receiving postoperative radiotherapy for resected pancreatic head Cancer JO - Int J Radiat Oncol VL - 83 UR - https://doi.org/10.1016/j.ijrobp.2011.05.045 DO - 10.1016/j.ijrobp.2011.05.045 ID - Nichols2012 ER - TY - JOUR AU - Burman, C. AU - Kutcher, G. J. AU - Emami, B. AU - Goitein, M. PY - 1991 DA - 1991// TI - Fitting of normal tissue tolerance data to an analytic function JO - Int J Radiat Oncol Biol Phys VL - 21 UR - https://doi.org/10.1016/0360-3016(91)90172-Z DO - 10.1016/0360-3016(91)90172-Z ID - Burman1991 ER - TY - STD TI - Lyman JT. Complication probability as assessed from dose-volume histograms. Radiat Res Suppl. 1985;8. https://doi.org/10.2307/3583506. ID - ref27 ER - TY - JOUR AU - Pan, C. AU - Dawson, L. AU - McGinn, C. AU - Lawrence, T. AU - Haken, R. PY - 2003 DA - 2003// TI - Analysis of radiation-induced gastric and duodenal bleeds using the Lyman-Kutcher-Burman model JO - Int J Radiat Oncol. VL - 57 UR - https://doi.org/10.1016/s0360-3016(03)01031-9 DO - 10.1016/s0360-3016(03)01031-9 ID - Pan2003 ER - TY - JOUR AU - Holyoake, D. L. P. AU - Aznar, M. AU - Mukherjee, S. AU - Partridge, M. AU - Hawkins, M. A. PY - 2017 DA - 2017// TI - Modelling duodenum radiotherapy toxicity using cohort dose-volume-histogram data JO - Radiother Oncol VL - 123 UR - https://doi.org/10.1016/j.radonc.2017.04.024 DO - 10.1016/j.radonc.2017.04.024 ID - Holyoake2017 ER - TY - JOUR AU - Chang, J. H. AU - Gehrke, C. AU - Prabhakar, R. PY - 2016 DA - 2016// TI - RADBIOMOD: a simple program for utilising biological modelling in radiotherapy plan evaluation JO - Phys Medica VL - 32 UR - https://doi.org/10.1016/j.ejmp.2015.10.091 DO - 10.1016/j.ejmp.2015.10.091 ID - Chang2016 ER - TY - JOUR AU - Jethwa, K. R. AU - Tryggestad, E. J. AU - Whitaker, T. J. PY - 2018 DA - 2018// TI - Initial experience with intensity modulated proton therapy for intact, clinically localized pancreas cancer: clinical implementation, dosimetric analysis, acute treatment-related adverse events, and patient-reported outcomes JO - Adv Radiat Oncol VL - 3 UR - https://doi.org/10.1016/j.adro.2018.04.003 DO - 10.1016/j.adro.2018.04.003 ID - Jethwa2018 ER - TY - JOUR AU - Beltran, C. AU - Schultz, H. L. AU - Anand, A. AU - Merrell, K. PY - 2020 DA - 2020// TI - Radiation biology considerations of proton therapy for gastrointestinal cancers JO - J Gastrointest Oncol VL - 11 UR - https://doi.org/10.21037/jgo.2019.06.08 DO - 10.21037/jgo.2019.06.08 ID - Beltran2020 ER - TY - JOUR AU - Paganetti, H. PY - 2017 DA - 2017// TI - Relating the proton relative biological effectiveness to tumor control and normal tissue complication probabilities assuming interpatient variability in α/β JO - Acta Oncol (Madr) VL - 56 UR - https://doi.org/10.1080/0284186X.2017.1371325 DO - 10.1080/0284186X.2017.1371325 ID - Paganetti2017 ER - TY - JOUR AU - Paganetti, H. AU - Niemierko, A. AU - Ancukiewicz, M. PY - 2002 DA - 2002// TI - Relative biological effectiveness (RBE) values for proton beam therapy JO - Int J Radiat Oncol Biol Phys VL - 53 UR - https://doi.org/10.1016/S0360-3016(02)02754-2 DO - 10.1016/S0360-3016(02)02754-2 ID - Paganetti2002 ER - TY - JOUR AU - Kavanagh, B. D. AU - Pan, C. C. AU - Dawson, L. A. PY - 2010 DA - 2010// TI - Radiation dose–volume effects in the stomach and small bowel JO - Int J Radiat Oncol. VL - 76 UR - https://doi.org/10.1016/j.ijrobp.2009.05.071 DO - 10.1016/j.ijrobp.2009.05.071 ID - Kavanagh2010 ER - TY - CHAP AU - Stützer, K. AU - Jakobi, A. AU - Haase, R. PY - 2014 DA - 2014// TI - Characterization of deformation vector fields for the registration of dose distribution in adaptive treatment planning and sequential boost protocols BT - Joint Conference of the SSRMP, DGMP, ÖGMP ID - Stützer2014 ER - TY - JOUR AU - Korevaar, E. W. AU - Habraken, S. J. M. AU - Scandurra, D. PY - 2019 DA - 2019// TI - Practical robustness evaluation in radiotherapy – a photon and proton-proof alternative to PTV-based plan evaluation JO - Radiother Oncol VL - 141 UR - https://doi.org/10.1016/j.radonc.2019.08.005 DO - 10.1016/j.radonc.2019.08.005 ID - Korevaar2019 ER - TY - JOUR AU - Paganetti, H. PY - 2015 DA - 2015// TI - Relating proton treatments to photon treatments via the relative biological effectiveness - should we revise current clinical practice? JO - Int J Radiat Oncol Biol Phys VL - 91 UR - https://doi.org/10.1016/j.ijrobp.2014.11.021 DO - 10.1016/j.ijrobp.2014.11.021 ID - Paganetti2015 ER -