LKB model parameters | |||||
---|---|---|---|---|---|
OAR | Reference | LKB parameters | Endpoint | ||
Parotid glands | n | D50 (Gy) | m | ||
 | Eisbruch et al. [26] | 1.00 | 28.40 | 0.18 | 25% xerostomia at 1 year |
Roesink et al. [27] | 1.00 | 39.00 | 0.45 | 25% xerostomia at 1 year | |
Mandible | Burman et al. [25] | 0.07 | 72.00 | 0.10 | necrosis |
Larynx | Rancati et al. [28] | 1.17 | 47.30 | 0.23 | grade ≥ 2 edema |
Spinal cord | 0.07 | 72.00 | 0.10 | myelophathy | |
NTCP = (1 + e-S)− 1 | |||||
OAR | Reference | S | Endpoint | ||
Thyroid gland | Boomsma et al. [31] | 0.011 + (0.062*Dmean) + (− 0.19*V) | hypothyroidism | ||
PCM and supraglottic larynx (SL) | |||||
 | Christianen et al. [32] | −6.09 + (Dmean(PCM) *0.057) + (Dmean(SL) *0.057) | SWALM6 | ||
Christianen et al. [32] | −6.89 + (Dmean(PCM) *0.049) + (Dmean(SL) *0.048) + (age*0.795) | problems with swallowing solid food |