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Table 1 Summary of NTCP modeling studies (SWALM6: physician-rated swallowing dysfunction 6 months after (CH) RT)

From: Clinical implication in the use of the AAA algorithm versus the AXB in nasopharyngeal carcinomas by comparison of TCP and NTCP values

LKB model parameters

OAR

Reference

LKB parameters

Endpoint

Parotid glands

n

D50 (Gy)

m

 

Eisbruch et al. [26]

1.00

28.40

0.18

25% xerostomia at 1 year

Roesink et al. [27]

1.00

39.00

0.45

25% xerostomia at 1 year

Mandible

Burman et al. [25]

0.07

72.00

0.10

necrosis

Larynx

Rancati et al. [28]

1.17

47.30

0.23

grade ≥ 2 edema

Spinal cord

Kirpatrick et al. [29], Emami et al. [30]

0.07

72.00

0.10

myelophathy

NTCP = (1 + e-S)− 1

OAR

Reference

S

Endpoint

Thyroid gland

Boomsma et al. [31]

0.011 + (0.062*Dmean) + (− 0.19*V)

hypothyroidism

PCM and supraglottic larynx (SL)

 

Christianen et al. [32]

−6.09 + (Dmean(PCM) *0.057) + (Dmean(SL) *0.057)

SWALM6

Christianen et al. [32]

−6.89 + (Dmean(PCM) *0.049) + (Dmean(SL) *0.048) + (age*0.795)

problems with swallowing solid food