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Table 4 Side effects after re-irradiation and the correlation to the overlapping volume. Abbreviations: V100 – the volume at re-irradiation with a cumulative dose of ≥100 Gy (EQD2). Toxicity was graded according to Radiation Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Radiation Morbidity Schema

From: Overlapping volumes in re-irradiation for head and neck cancer – an important factor for patient selection

Side effects after re-irradiationa

Acute

Late

V100 < mean

V100 > mean

V100 < mean

V100 > mean

n

%

n

%

n

%

n

%

Grade 0–2

24

89

13

57

13

59

5

33

Grade ≥ 3

3

11

10

43

9

41

10

67

  1. p-value = 0.023
  2. p-value = 0.229
  3. a at least one grade 0–2, or grade ≥ 3 respectively