Fig. 1

MRI lesion volumes and histological grade as a function of mouse strain and time post-irradiation. Plots show the T2-weighted (Panel a) and T1-weighted (Panel b) lesion size (in mm³) and histological grade (Panel c) over time (in weeks) for mice that received 80 Gy. Data includes both substrains for each strain and both sexes. Symbols indicate the mean and the error bars are standard deviation. For T2-weighted scans, BALB/c mice develop radiation necrosis faster and develop larger lesion volumes. T1-weighted scans may indicate a similar result as the T2-weighted scans, although the larger error bars due to more variance in the data make this data harder to interpret. The histological data are harder to interpret, although they do appear to indicate not too much difference on a strain basis