From: Fatigue following radiotherapy of low-risk early breast cancer – a randomized controlled trial of intraoperative electron radiotherapy versus standard hypofractionated whole-breast radiotherapy: the COSMOPOLITAN trial (NCT03838419)
Organ at risk
Dose constraints
Heart
Dmean < 3 Gy, Dmax < 30 Gy (minor violation < 40 Gy)
Ipsilateral Lung
Dmean < 8 Gy, V20Gy < 10% (minor violation < 15%)
Contralateral Breast
Dmean < 3 Gy, Dmax < 20 Gy
Spinal cord
Dmax < 45 Gy