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Table 1 Means and standard deviations of dose volume histogram (DVH) metrics in target and normal organs over 13 patients. All plans were prescribed by coverage according to ICRU 91

From: On the pitfalls of PTV in lung SBRT using type-B dose engine: an analysis of PTV and worst case scenario concepts for treatment plan optimization

 

PTVITV(i)

PTVVH(ii)

WCSCITV(iii)

WCSGTV(iv)

p-value< 0.05

GTV

D98 (Gy)

60.6 ± 1.8 (56.1–63.7)

59.6 ± 1.5 (57.0–62.3)

57.8 ± 1.7 (54.8–59.6)

56.4 ± 1.0 (55.2–58.6)

(i)-(iii); (i)-(iv); (ii)-(iv)

D50 (Gy)

65.7 ± 2.2 (59.7–68.1)

63.1 ± 2.2 (60.0–66.5)

63.7 ± 2.2 (59.9–67.2)

60.5 ± 2.1 (56.4–64.8)

(i)-(iv)

D2 (Gy)

69.3 ± 2.3 (65.1–76.3)

65.4 ± 3.0 (61.3–70.7)

67.2 ± 3.5 61.6–72.5)

64.3 ± 2.9 (60.5–70.7)

(i)-(iv)

Chest Wall

V30Gy (cm3)

26.4 ± 16.5 (4.0–60.9)

19.3 ± 9.9 (1.0–38.1)

14.1 ± 8.7 (0.4–31.4)

12.4 ± 7.7 (0.0–29.5)

(i)-(iii); (i)-(iv); (ii)-(iii); (ii)-(iv)

Lung

V5Gy (cm3)

18.1 ± 5.7 (3.3–14.0)

18.7 ± 5.0 (3.6–13.5)

18.1 ± 5.8 (3.1–13.4)

17.0 ± 5.6 (2.8–13.4)

(i)-(iv); (ii)-(iv)

V20Gy (cm3)

8.4 ± 3.7 (9.1–31.3)

7.8 ± 3.3 (9.5–28.3)

7.4 ± 3.2 (8.3–30.7)

6.9 ± 3.3 (7.8–29.8)

(i)-(iii); (i)-(iv); (ii)-(iii); (ii)-(iv)

MLD (Gy)

4.8 ± 1.7 (2.2–7.9)

4.7 ± 1.5 (2.3–7.2)

4.6 ± 1.6 (2.1–7.1)

4.2 ± 1.5 (1.9–7.1)

(i)-(iv); (ii)-(iv)

  1. Abbreviation: GTV gross tumor volume, Dx(Gy) Dose to x % of the GTV, where x = 98, 50 and 2 represent the near–minimum, median and near–maximum dose, respectively, VxGy(cm3) volume receiving at least x Gy, MLD (Gy) mean normal lung dose; posthoc pairwise comparisons showing p-values < 0.05 are indicated when the Freidman’s tests were found statistical significant