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Table 2 Summary of the planning objectives and average results (uncertainty expressed as 1 standard deviation) for the main organs at risk investigated in the study) together with the presence of statistical significance difference among any couple of datasets

From: Volumetric modulated arc therapy versus intensity-modulated proton therapy in neoadjuvant irradiation of locally advanced oesophageal cancer

 

Objective

RA_RP

IMPT_2F

IMPT_3F

p

Lungs

Mean [Gy]

≤12Gy

8.6 ± 2.9

3.2 ± 1.5

2.9 ± 1.2

A,B,C

V20Gy[%]

≤20%

10.5 ± 5.6

6.9 ± 4.2

5.9 ± 2.6

A,B,C

Whole heart

Mean [Gy]

≤10Gy

9.9 ± 1.9

3.7 ± 1.3

4.0 ± 1.4

B,C

V30Gy

≤10%

5.9 ± 2.9

4.9 ± 2.2

4.9 ± 2.3

B,C

Left ventricle

Mean [Gy]

Mimimise

6.5 ± 1.6

1.9 ± 1.5

1.9 ± 1.6

B,C

D0.1cm3%[Gy]

 

23.9 ± 9.2

25.2 ± 10.9

25.1 ± 11.4

B,C

Left Anterior Descending artery

Mean [Gy]

Mimimise

3.1 ± 0.5

0.1 ± 0.1

0.1 ± 0.2

B,C

D0.1cm3[Gy]

Mimimise

5.3 ± 1.1

0.9 ± 2.4

3.8 ± 5.9

A,B,C

Left coronary artery

Mean [Gy]

Mimimise

6.2 ± 4.2

1.5 ± 3.4

2.9 ± 4.7

A,B,C

D0.1cm3[Gy]

Mimimise

10.9 ± 14.1

6.5 ± 15.5

8.0 ± 15.4

A,B,C

Liver

Mean

≤15Gy

11.5 ± 1.8

3.8 ± 1.8

3.6 ± 1.2

B,C

Left kidney

Mean [Gy]

≤15Gy

3.4 ± 1.9

2.1 ± 1.9

1.7 ± 1.5

A,B,C

V20Gy[%]

≤32%

1.8 ± 2.2

1.7 ± 1.7

0.9 ± 1.0

A

Right kidney

Mean [Gy]

≤15Gy

2.9 ± 2.1

1.6 ± 1.8

1.2 ± 1.3

A,B,C

V20Gy[%]

≤32%

1.1 ± 2.2

1.9 ± 3.1

0.4 ± 0.9

A,C

Stomach

Mean [Gy]

Mimimise

8.5 ± 6.9

3.4 ± 6.9

3.5 ± 6.7

B,C

D1%[Gy]

Mimimise

31.3 ± 11.1

28.8 ± 14.0

28.8 ± 13.6

B,C

D1cm3[Gy]

Mimimise

32.5 ± 11.5

30.7 ± 14.1

30.7 ± 13.6

B,C

Spleen

Mean [Gy]

Mimimise

8.2 ± 2.2

4.6 ± 4.0

2.7 ± 3.1

A,B,C

D1%[Gy]

Mimimise

23.4 ± 7.6

22.9 ± 11.3

21.5 ± 8.5

C

Bowel

Mean [Gy]

Mimimise

5.6 ± 3.5

0.8 ± 0.9

1.4 ± 1.49

A,B,C

D1%[Gy]

Mimimise

17.7 ± 9.6

14.9 ± 11.3

16.2 ± 10.7

–

D1cm3[Gy]

 

19.8 ± 11.2

19.4 ± 12.7

20.1 ± 12.1

A

Spinal canal

D1%[Gy]

Mimimise

16.6 ± 2.1

22.2 ± 4.9

12.3 ± 1.7

A,B,C

D0.1cm3%[Gy]

Mimimise

17.0 ± 2.2

23.5 ± 4.6

13.2 ± 1.8

A,B,C

  1. P: Statistical significance: A: IMPT_2F vs IMPT_3F; B: IMPT_2F vs RA_RP; C: IMPT_3F vs RP_RP
  2. Dx Dose received by x volume, Vx Volume receiving x dose, RA_RP RapidArc Volumetric modulated arc therapy with RapidPlan optimization, IMPT Intensity modulated proton therapy with robust optimization (2 fields: _2F; 3 fields: _3F)
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