Skip to main content

Table 2 Summary of the planning objectives and average results (uncertainty expressed as 1 standard deviation) for the main organs at risk investigated in the study) together with the presence of statistical significance difference among any couple of datasets

From: Volumetric modulated arc therapy versus intensity-modulated proton therapy in neoadjuvant irradiation of locally advanced oesophageal cancer

  Objective RA_RP IMPT_2F IMPT_3F p
Lungs
Mean [Gy] ≤12Gy 8.6 ± 2.9 3.2 ± 1.5 2.9 ± 1.2 A,B,C
V20Gy[%] ≤20% 10.5 ± 5.6 6.9 ± 4.2 5.9 ± 2.6 A,B,C
Whole heart
Mean [Gy] ≤10Gy 9.9 ± 1.9 3.7 ± 1.3 4.0 ± 1.4 B,C
V30Gy ≤10% 5.9 ± 2.9 4.9 ± 2.2 4.9 ± 2.3 B,C
Left ventricle
Mean [Gy] Mimimise 6.5 ± 1.6 1.9 ± 1.5 1.9 ± 1.6 B,C
D0.1cm3%[Gy]   23.9 ± 9.2 25.2 ± 10.9 25.1 ± 11.4 B,C
Left Anterior Descending artery
Mean [Gy] Mimimise 3.1 ± 0.5 0.1 ± 0.1 0.1 ± 0.2 B,C
D0.1cm3[Gy] Mimimise 5.3 ± 1.1 0.9 ± 2.4 3.8 ± 5.9 A,B,C
Left coronary artery
Mean [Gy] Mimimise 6.2 ± 4.2 1.5 ± 3.4 2.9 ± 4.7 A,B,C
D0.1cm3[Gy] Mimimise 10.9 ± 14.1 6.5 ± 15.5 8.0 ± 15.4 A,B,C
Liver
Mean ≤15Gy 11.5 ± 1.8 3.8 ± 1.8 3.6 ± 1.2 B,C
Left kidney
Mean [Gy] ≤15Gy 3.4 ± 1.9 2.1 ± 1.9 1.7 ± 1.5 A,B,C
V20Gy[%] ≤32% 1.8 ± 2.2 1.7 ± 1.7 0.9 ± 1.0 A
Right kidney
Mean [Gy] ≤15Gy 2.9 ± 2.1 1.6 ± 1.8 1.2 ± 1.3 A,B,C
V20Gy[%] ≤32% 1.1 ± 2.2 1.9 ± 3.1 0.4 ± 0.9 A,C
Stomach
Mean [Gy] Mimimise 8.5 ± 6.9 3.4 ± 6.9 3.5 ± 6.7 B,C
D1%[Gy] Mimimise 31.3 ± 11.1 28.8 ± 14.0 28.8 ± 13.6 B,C
D1cm3[Gy] Mimimise 32.5 ± 11.5 30.7 ± 14.1 30.7 ± 13.6 B,C
Spleen
Mean [Gy] Mimimise 8.2 ± 2.2 4.6 ± 4.0 2.7 ± 3.1 A,B,C
D1%[Gy] Mimimise 23.4 ± 7.6 22.9 ± 11.3 21.5 ± 8.5 C
Bowel
Mean [Gy] Mimimise 5.6 ± 3.5 0.8 ± 0.9 1.4 ± 1.49 A,B,C
D1%[Gy] Mimimise 17.7 ± 9.6 14.9 ± 11.3 16.2 ± 10.7
D1cm3[Gy]   19.8 ± 11.2 19.4 ± 12.7 20.1 ± 12.1 A
Spinal canal
D1%[Gy] Mimimise 16.6 ± 2.1 22.2 ± 4.9 12.3 ± 1.7 A,B,C
D0.1cm3%[Gy] Mimimise 17.0 ± 2.2 23.5 ± 4.6 13.2 ± 1.8 A,B,C
  1. P: Statistical significance: A: IMPT_2F vs IMPT_3F; B: IMPT_2F vs RA_RP; C: IMPT_3F vs RP_RP
  2. Dx Dose received by x volume, Vx Volume receiving x dose, RA_RP RapidArc Volumetric modulated arc therapy with RapidPlan optimization, IMPT Intensity modulated proton therapy with robust optimization (2 fields: _2F; 3 fields: _3F)