Volumetric modulated arc therapy versus intensity-modulated proton therapy in neoadjuvant irradiation of locally advanced oesophageal cancer

Table 1 Summary of the planning objectives and average results (uncertainty expressed as 1 standard deviation) for the gross target volume (GTV), the clinical target volume (CTV) and for the planning target volume (PTV) together with the presence of statistical significance difference among any couple of datasets

	Objective	RA_RP	IMPT_3F	IMPT_2F	p
GTV
Mean [Gy]	41.4	41.5 ± 0.4	41.4 ± 0.4	41.4 ± 0.4	–
D_1%[Gy]	Minimize	42.2 ± 0.2	42.4 ± 0.3	42.4 ± 0.3	–
V_98%[%]	≥98	99.7 ± 1.1	99.0 ± 1.3	98.2 ± 2.1	B,C
CTV
Mean [Gy]	41.4	41.6 ± 0.1	41.4 ± 0.1	41.4 ± 0.1	–
D_1%[Gy]	Minimize	42.4 ± 0.2	42.5 ± 0.3	42.5 ± 0.3	–
V_98%[%]	≥98	99.5 ± 0.6	98.5 ± 1.1	97.8 ± 1.8	B,C
PTV
Mean [Gy]	41.4	41.4 ± 0.0	41.4 ± 0.0	41.4 0.0	–
D_1%[Gy]	Minimize	42.7 ± 0.3	42.8 ± 0.2	42.8 ± 0.2	–
V_98%[%]	≥90	89.9 ± 1.2	93.9 ± 1.7	94.1 ± 2.0	B,C
V_95%[%]	≥95	97.2 ± 0.7	98.3 ± 0.7	98.4 ± 0.7	B,C
HI [%]	minimize	5.6 ± 0.6	4.5 ± 0.8	4.4 ± 0.9	B,C
CI_Paddick	minimize	0.88 ± 0.01	0.89 ± 0.02	0.89 ± 0.02	–

P: Statistical significance: A: IMPT_2F vs IMPT_3F; B: IMPT_2F vs RA_RP; C: IMPT_3F vs RP_RP
D_x Dose received by x volume, V_x Volume receiving x dose, CI_Paddick Conformity index, HI Homogeneity index, RA_RP RapidArc Volumetric modulated arc therapy with RapidPlan optimization, IMPT Intensity modulated proton therapy with robust optimization (2 fields: _2F; 3 fields: _3F)

ISSN: 1748-717X