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Table 1 Summary of the planning objectives and average results (uncertainty expressed as 1 standard deviation) for the gross target volume (GTV), the clinical target volume (CTV) and for the planning target volume (PTV) together with the presence of statistical significance difference among any couple of datasets

From: Volumetric modulated arc therapy versus intensity-modulated proton therapy in neoadjuvant irradiation of locally advanced oesophageal cancer

 

Objective

RA_RP

IMPT_3F

IMPT_2F

p

GTV

Mean [Gy]

41.4

41.5 ± 0.4

41.4 ± 0.4

41.4 ± 0.4

–

D1%[Gy]

Minimize

42.2 ± 0.2

42.4 ± 0.3

42.4 ± 0.3

–

V98%[%]

≥98

99.7 ± 1.1

99.0 ± 1.3

98.2 ± 2.1

B,C

CTV

Mean [Gy]

41.4

41.6 ± 0.1

41.4 ± 0.1

41.4 ± 0.1

–

D1%[Gy]

Minimize

42.4 ± 0.2

42.5 ± 0.3

42.5 ± 0.3

–

V98%[%]

≥98

99.5 ± 0.6

98.5 ± 1.1

97.8 ± 1.8

B,C

PTV

Mean [Gy]

41.4

41.4 ± 0.0

41.4 ± 0.0

41.4 0.0

–

D1%[Gy]

Minimize

42.7 ± 0.3

42.8 ± 0.2

42.8 ± 0.2

–

V98%[%]

≥90

89.9 ± 1.2

93.9 ± 1.7

94.1 ± 2.0

B,C

V95%[%]

≥95

97.2 ± 0.7

98.3 ± 0.7

98.4 ± 0.7

B,C

HI [%]

minimize

5.6 ± 0.6

4.5 ± 0.8

4.4 ± 0.9

B,C

CIPaddick

minimize

0.88 ± 0.01

0.89 ± 0.02

0.89 ± 0.02

–

  1. P: Statistical significance: A: IMPT_2F vs IMPT_3F; B: IMPT_2F vs RA_RP; C: IMPT_3F vs RP_RP
  2. Dx Dose received by x volume, Vx Volume receiving x dose, CIPaddick Conformity index, HI Homogeneity index, RA_RP RapidArc Volumetric modulated arc therapy with RapidPlan optimization, IMPT Intensity modulated proton therapy with robust optimization (2 fields: _2F; 3 fields: _3F)