Fig. 1

Examples of patients with desmoid tumors: A 27-year-old patient with a progressive, gigantic, FAP-associated mesenteric desmoid tumor, treatment was performed with photon-IMRT up to 50.4 Gy in 28 fractions, B: The patient developed a new symptomatic desmoid tumor of the abdominal wall 7 years after the primary treatment and was treated with protons 56 Gy (RBE) in 28 fractions. The mesenteric desmoid regressed in size, and stabilized with a cystic appearance on CT and MRI (not shown). C: Thirty-two-year-old patient who was pregnant at diagnosis of a gigantic cervico-thoracic desmoid tumor. The patient was treated beginning in the 28th week of pregnancy with protons, however the tumor progressed rapidly and the treatment was discontinued at 30 Gy (RBE). Caesarean section was performed and treatment with methotrexate and vinorelbine initiated. The tumor regress significantly after that