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Table 3 Model Parameter Values

From: Investigating the loco-regional control of simultaneous integrated boost intensity-modulated radiotherapy with different radiation fraction sizes for locally advanced non-small-cell lung cancer: clinical outcomes and the application of an extended LQ/TCP model

Parameter

LQ

LQRG

Value

95% CI

ρ (cm−3)

7.965 × 109

2.296 × 109

[1.23 × 109, 4.19 × 109]

α (Gy−1)

0.3932

0.06691

[0.0656, 0.0721]

β (Gy−2)

0.0429

0.1039

[0.0071, 0.1996]

σ2 (Gy−2)

/

0.1939

[0.0893, 0.2014]

τR (hour)

/

6.32

[5.51, 6.73]

τS (hour)

/

3.04

[1.12,4.99]

τP (day)

113.8

84.55

[30.1, 176.27]

Tk (hour)

246.06

533.5

[0.024, 1979.5]

Kc

/

2.367 × 109

[2.1 × 109, 3.12 × 109]

σk

/

1.03 × 109

[7.75 × 108, 1.2 × 109]

δ

/

0.2645

[0.2368,0.2817]

α/β in LQ and

α/βeff in LQRG (Gy)*

9.2

10.06

/

  1. LQ Linear-quadratic model, LQRG LQ model incorporating cell repair, redistribution, reoxygenation, regrowth and Gompertzian tumor growth