Table 5 Univariable Analysis (Log-rank)
Local recurrence | Overall survival | |||
|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | |
Age (years) | ||||
> 42.5 (=median) | 0.91 (0.46–1.82) | 0.80 | 2.74 (1.11–7.69) | 0.03 |
Sekhar score | ||||
< 8 | 0.31 (0.09–1.03) | 0.04 | 1.03 (0.34–2.64) | 0.95 |
8–12 | 1.29 (0.62–2.66) | 0.49 | 0.73 (0.31–1.75) | 0.46 |
> 12 | 1.83 (0.82–4.06) | 0.13 | 1.57 (0.51–4.04) | 0.37 |
Number of sites involved | ||||
> 3 (= median) | 0.91 (0.46–1.81) | 0.79 | 0.90 (0.38–2.17) | 0.81 |
Vascular involvement (number of vessels) | ||||
> 1 (= median) | 1.90 (0.54–2.16) | 0.82 | 0.80 (0.34–1.92) | 0.61 |
≤ 2 vs > 2 | 1.00 (0.43–2.31) | 0.99 | 1.12 (0.37–2.85) | 0.83 |
Intradural invasion | ||||
yes vs. no | 1.38 (0.42–4.57) | 0.60 | 0.75 (0.25–3.20) | 0.64 |
PT for recurrent disease | ||||
yes vs. no | 3.19 (1.57–6.50) | < 0.01 | 1.92 (0.68–4.73) | 0.17 |
Number of oncological surgeries | ||||
> 1 (= median) | 1.33 (0.67–2.64) | 0.42 | 1.41 (0.60–3.45) | 0.44 |
≤ 2 vs > 2 | 0.38 (0.17–0.85 | 0.01 | 0.28 (0.12–0.76) | < 0.01 |
Maximum extent of surgery | ||||
GTR vs. STR or Biopsy | 1.26 (0.38–4.11) | 0.72 | 1.62 (0.26–5.67) | 0.51 |
Surgical complications | ||||
yes vs. no | 1.90 (0.94–3.81) | 0.07 | 2.84 (1.20–6.98) | 0.01 |
Gross tumor volume (cc) | ||||
> 26 (= median) | 1.26 (0.63–2.50) | 0.51 | 2.89 (1.13–8.85) | 0.03 |
≤ 40 vs. > 40 | 2.34 (1.17–4.69) | 0.01 | 0.19 (0.07–0.46) | < 0.01 |
Brainstem compression before PT | ||||
yes vs. no | 2.53 (1.27–5.01) | < 0.01 | 1.44 (0.55–3.47) | 0.43 |
OA compression before PT | ||||
yes vs. no | 2.21 (1.02–4.76) | 0.04 | 2.14 (0.76–5.29) | 0.11 |
Brainstem or OA compression before PT | ||||
yes vs. no | 2.46 (1.22–4.96) | < 0.01 | 1.64 (0.69–3.95) | 0.25 |