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Table 5 Univariable Analysis (Log-rank)

From: Prognostic impact of the “Sekhar grading system for cranial Chordomas” in patients treated with pencil beam scanning proton therapy: an institutional analysis

 Local recurrenceOverall survival
HR (95% CI)pHR (95% CI)p
Age (years)
  > 42.5 (=median)0.91 (0.46–1.82)0.802.74 (1.11–7.69)0.03
Sekhar score
  < 80.31 (0.09–1.03)0.041.03 (0.34–2.64)0.95
 8–121.29 (0.62–2.66)0.490.73 (0.31–1.75)0.46
  > 121.83 (0.82–4.06)0.131.57 (0.51–4.04)0.37
Number of sites involved
  > 3 (= median)0.91 (0.46–1.81)0.790.90 (0.38–2.17)0.81
Vascular involvement (number of vessels)
  > 1 (= median)1.90 (0.54–2.16)0.820.80 (0.34–1.92)0.61
  ≤ 2 vs > 21.00 (0.43–2.31)0.991.12 (0.37–2.85)0.83
Intradural invasion
 yes vs. no1.38 (0.42–4.57)0.600.75 (0.25–3.20)0.64
PT for recurrent disease
 yes vs. no3.19 (1.57–6.50)< 0.011.92 (0.68–4.73)0.17
Number of oncological surgeries
  > 1 (= median)1.33 (0.67–2.64)0.421.41 (0.60–3.45)0.44
  ≤ 2 vs > 20.38 (0.17–0.850.010.28 (0.12–0.76)< 0.01
Maximum extent of surgery
 GTR vs. STR or Biopsy1.26 (0.38–4.11)0.721.62 (0.26–5.67)0.51
Surgical complications
 yes vs. no1.90 (0.94–3.81)0.072.84 (1.20–6.98)0.01
Gross tumor volume (cc)
  > 26 (= median)1.26 (0.63–2.50)0.512.89 (1.13–8.85)0.03
  ≤ 40 vs. >  402.34 (1.17–4.69)0.010.19 (0.07–0.46)< 0.01
Brainstem compression before PT
 yes vs. no2.53 (1.27–5.01)< 0.011.44 (0.55–3.47)0.43
OA compression before PT
 yes vs. no2.21 (1.02–4.76)0.042.14 (0.76–5.29)0.11
Brainstem or OA compression before PT
 yes vs. no2.46 (1.22–4.96)< 0.011.64 (0.69–3.95)0.25
  1. PT proton therapy, GTR gross total resection, STR subtotal resection, cc cm3, OA optic apparatus