Predicting per-lesion local recurrence in locally advanced non-small cell lung cancer following definitive radiation therapy using pre- and mid-treatment metabolic tumor volume

Table 2 Univariable and multivariable competing risk regression accounting for clustered analysis and competing risk of death

		Local recurrence (n = 45 events)
Variable		Univariable	MVA1	MVA2
Age	HR	1.00
	95% CI	0.96–1.05
	P	0.84
ΔMTV	HR	1.09
	95% CI	0.96–1.24
	P	0.19
Log(MTV_pre)	HR	2.43		2.01
	95% CI	1.56–3.78		1.25–3.23
	P	8.4e-5		0.004
Log(MTV_mid)	HR	2.33	2.12
	95% CI	1.61–3.37	1.47–3.08
	P	6.8e-5	7.1e-5
Primary Lesion (non-nodal target)	HR	3.60	1.37	1.79
	95% CI	1.86–6.95	0.67–2.79	0.86–3.72
	P	0.0001	0.38	0.12
RT dose	HR	1.06
	95% CI	0.97–1.16
	P	0.17
Histology
Adenocarcinoma (ref)	HR	–
	95% CI	–
	P	–
SCC	HR	1.89
	95% CI	0.80–4.46
	P	0.15
All others	HR	1.27
	95% CI	0.30–5.45
	P	0.75

Abbreviations: MVA multivariable analysis; MTV_pre pretreatment metabolic tumor volume; MTV_mid mid-treatment metabolic tumor volume; RT radiation therapy; SCC squamous cell carcinoma; ref. reference

ISSN: 1748-717X