| Univariate Analyses | Multivariate Analysis | ||||
---|---|---|---|---|---|---|
HR | 95% CI | p-value | HR | 95% CI | p-value | |
Age | 0.994 | 0.977–1.011 | 0.491 |  |  |  |
Gender | 1.195 | 0.725–1.970 | 0.484 |  |  |  |
Volume | 0.956 | 0.933–0.980 | 0.000 |  |  |  |
Integral dose | 0.549 | 0.381–0.792 | 0.001 | 0.540 | 0.376–0.775 | 0.001 |
Dmean | 1.027 | 0.987–1.068 | 0.189 | 1.041 | 1.002–1.080 | 0.038 |
Isodose | 0.988 | 0.908–1.075 | 0.777 |  |  |  |
Dmax | 1.026 | 0.991–1.062 | 0.150 |  |  |  |
Prescription dose | 1.578 | 0.984–1.020 | 0.209 |  |  |  |
Re-irradiation yes/no no as reference | 0.732 | 0.315–1.699 | 0.467 |  |  |  |
Multiple sclerosis yes/no no as reference | 0.340 | 0.162–0.714 | 0.004 | 0.332 | 0.156–1.002 | 0.004 |