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Table 3 Univariate Cox-regression analysis regarding the effects of clinical and pathological parameters on OS and PFS

From: The value of moderate dose escalation for re-irradiation of recurrent or second primary head-and-neck cancer

 

OS

PFS

Parameter

HR

CI 95%

p-value

HR

CI 95%

p-value

Age ≥ 65 / < 65 years

1.398

0.602–3.246

0.435

1.788

0.805–3.971

0.153

Gender male / female

3.832

0.898–16.352

0.070

1.646

0.564–4.800

0.361

ECOG 1–3 / ECOG 0

1.609

0.599–4.326

0.346

1.940

0.733–5.138

0.182

Smoker / non-smoker

1.603

0.690–3.722

0.272

1.743

0.786–3.867

0.172

rT3–4 / rT0–2

2.206

1.002–4.856

0.049

2.940

1.351–6.397

0.007

rN2–3 / rN0–1

0.680

0.255–1.814

0.441

0.636

0.256–1.580

0.330

M+ / M0

1.746

0.654–4.662

0.266

1.422

0.573–3.529

0.448

G3 / G1–2

0.882

0.396–1.966

0.759

1.072

0.494–2.327

0.860

No laryngeal carcinoma / laryngeal carcinoma

1.351

0.506–3.608

0.549

1.537

0.580–4.070

0.387

No PET-CT / PET-CT

0.880

0.388–1.998

0.760

0.837

0.385–1.817

0.652

No MRI / MRI

1.555

0.619–3.907

0.348

2.618

1.101–6.225

0.029

No boost / boost

4.544

1.354–15.256

0.014

2.330

0.803–6.758

0.119

≤ 50 Gy / > 50 Gy

2.000

0.896–4.466

0.091

1.752

0.801–3.833

0.160

Radiotherapy non-completed / completed

2.665

0.981–7.240

0.055

2.049

0.770–5.452

0.151

No chemotherapy / chemotherapy

1.019

0.448–2.321

0.964

0.801

0.368–1.742

0.576

Cisplatin / cetuximab

1.266

0.426–3.767

0.671

1.465

0.496–4.324

0.489