Table 4 Stereotactic Body Radiotherapy (SBRT) vs. Surgery for lung cancer

ROSEL/ STARS

Chang (Lancet Oncol 2015)

58 Pat. 2 rand., prosp. Studies

T1–2 N0, < 4 cm

54 Gy in 3 Fx (peripher) o. 50 Gy in 4 Fx (zentral) vs. surgery

SBRT vs. surgery

3y-OS: 95 vs. 79% (s)

LC: 94% vs. 100% (n.s.)

>°III Tox: 10 vs 44%

Zheng et al. IJROBP 2014

Metanalyse, 40 studies of SBRT and 23 Studies with surgery St. I NSCLC

Median Age 74 J. vs. 66 J.

5-year OS 40% vs. 66% (lobectomie) vs. 71% (sublobectomie)

Stokes et al. JCO 01/2018

30 & 90 day mortality

National Database, 76,623 patients OP (78% lobectomy, 20% sublobar resection, 2% pneumonectomy) vs. 8216 patients SBRT

Propensity score matching

surgical mortality rates were significantly higher with increased extent of resection and age at

30 days, 2.41% vs 0.79% (s), 90 days, 4.23% vs 2.82% (s) with matched pairs